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A Topological Framework for the Computation of the HOMFLY Polynomial and Its Application to Proteins

A Topological Framework for the Computation of the HOMFLY Polynomial and Its Application to Proteins

Polymers can be modeled as open polygonal paths and their closure generates knots. Knotted proteins detection is currently achieved via high-throughput methods based on a common framework insensitive to the handedness of knots. Here we propose a topological framework for the computation of the HOMFLY polynomial, an handedness-sensitive invariant. Our …