Analysis of Case-Control Association Studies: SNPs, Imputation and Haplotypes
Analysis of Case-Control Association Studies: SNPs, Imputation and Haplotypes
Although prospective logistic regression is the standard method of analysis for case-control data, it has been recently noted that in genetic epidemiologic studies one can use the ``retrospective'' likelihood to gain major power by incorporating various population genetics model assumptions such as Hardy-Weinberg-Equilibrium (HWE), gene-gene and gene-environment independence. In this …