Tipping the Balance: Robustness of Tip Cell Selection, Migration and Fusion in Angiogenesis
Tipping the Balance: Robustness of Tip Cell Selection, Migration and Fusion in Angiogenesis
Vascular abnormalities contribute to many diseases such as cancer and diabetic retinopathy. In angiogenesis new blood vessels, headed by a migrating tip cell, sprout from pre-existing vessels in response to signals, e.g., vascular endothelial growth factor (VEGF). Tip cells meet and fuse (anastomosis) to form blood-flow supporting loops. Tip cell …