Prolonging assembly through dissociation: A self-assembly paradigm in microtubules
Prolonging assembly through dissociation: A self-assembly paradigm in microtubules
We study a one-dimensional model of microtubule assembly/disassembly in which GTP bound to tubulins within the microtubule undergoes stochastic hydrolysis. In contrast to models that only consider a cap of GTP-bound tubulin, stochastic hydrolysis allows GTP-bound tubulin remnants to exist within the microtubule. We find that these buried GTP remnants …