Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation
Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation
We show that the effect of stress on the reproductive fitness of noisy cell populations can be modelled as first-passage time problem, and demonstrate that even relatively short-lived fluctuations in gene expression can ensure long-term survival of a drug-resistant population. We examine how this effect contributes to the development of …