Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems
Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems
It is becoming increasingly clear that bistability (or, more generally, multistability) is an important recurring theme in cell signaling. Bistability may be of particular relevance to biological systems that switch between discrete states, generate oscillatory responses, or “remember” transitory stimuli. Standard mathematical methods allow the detection of bistability in some …