Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer
Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer
Colorectal cancer is initiated in colonic crypts. A succession of genetic mutations or epigenetic changes can lead to homeostasis in the crypt being overcome, and subsequent unbounded growth. We consider the dynamics of a single colorectal crypt by using a compartmental approach [Tomlinson IPM, Bodmer WF (1995) Proc Natl Acad …