Craniofacial variability and morphological integration in mice susceptible to cleft lip and palate
Craniofacial variability and morphological integration in mice susceptible to cleft lip and palate
A/WySnJ mice are an inbred strain that develops cleft lip with or without cleft palate (CL/P) with a frequency of 25-30% and a predominantly unilateral expression pattern. As in humans, the pattern of incomplete penetrance, and variable and frequent unilateral expression suggests a role for altered regulation of variability (developmental …