Gene expression dynamics with stochastic bursts: Construction and exact results for a coarse-grained model
Gene expression dynamics with stochastic bursts: Construction and exact results for a coarse-grained model
We present a theoretical framework to analyze the dynamics of gene expression with stochastic bursts. Beginning with an individual-based model which fully accounts for the messenger RNA (mRNA) and protein populations, we propose a novel expansion of the master equation for the joint process. The resulting coarse-grained model reduces the …