Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis
Understanding cell-fate decisions during tumorigenesis and metastasis is a major challenge in modern cancer biology. One canonical cell-fate decision that cancer cells undergo is Epithelial-to-Mesenchymal Transition (EMT) and its reverse Mesenchymal-to-Epithelial Transition (MET). While transitioning between these two phenotypes – epithelial and mesenchymal, cells can also attain a hybrid epithelial/ …