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Characterization of knot complements in the n-sphere

Characterization of knot complements in the n-sphere

Knot complements in the n-sphere are characterized. A connected open subset W of $S^n$ is homeomorphic with the complement of a locally flat (n-2)-sphere in $S^n$, n ≥ 4, if and only if the first homology group of W is infinite cyclic, W has one end, and