The fallacy of enrolling only high-risk subjects in cancer prevention trials: Is there a "free lunch"?
The fallacy of enrolling only high-risk subjects in cancer prevention trials: Is there a "free lunch"?
There is a common belief that most cancer prevention trials should be restricted to high-risk subjects in order to increase statistical power. This strategy is appropriate if the ultimate target population is subjects at the same high-risk. However if the target population is the general population, three assumptions may underlie …