Physical Limit to Concentration Sensing Amid Spurious Ligands
Physical Limit to Concentration Sensing Amid Spurious Ligands
To adapt their behavior in changing environments, cells sense concentrations by binding external ligands to their receptors. However, incorrect ligands may bind nonspecifically to receptors, and when their concentration is large, this binding activity may interfere with the sensing of the ligand of interest. Here, I derive analytically the physical …