Bayesian inference on quasi-sparse count data

Abstract

There is growing interest in analysing high-dimensional count data, which often exhibit quasi-sparsity corresponding to an overabundance of zeros and small nonzero counts. Existing methods for analysing multivariate count data via Poisson or negative binomial log-linear hierarchical models with zero-inflation cannot flexibly adapt to quasi-sparse settings. We develop a new class of continuous local-global shrinkage priors tailored to quasi-sparse counts. Theoretical properties are assessed, including flexible posterior concentration and stronger control of false discoveries in multiple testing. Simulation studies demonstrate excellent small-sample properties relative to competing methods. We use the method to detect rare mutational hotspots in exome sequencing data and to identify North American cities most impacted by terrorism.

Locations

• Biometrika - View - PDF
• PubMed Central - View
• Europe PMC (PubMed Central) - View - PDF
• PubMed - View