Efficiencies of platform clinical trials: A vision of the future

Benjamin R. Saville, Scott Berry

Type: Article

Publication Date: 2016-02-17

Citations: 256

DOI: https://doi.org/10.1177/1740774515626362

View Publication

Locations

PubMed - View
Clinical Trials - View

Similar Works

Action	Title	Year	Authors
+	Efficiencies of Platform Trials	2018	Satrajit Roychoudhury Ohad Amit
+	Platform Trials	2023	Haitao Pan Ying Yuan
+	Why and how should we simulate platform trials? Learnings from EU-PEARL	2025	Elias Laurin Meyer Tobias Mielke Marta Bofill Roig Michael Freitag Peter Jacko Pavla Krotka Peter Mesenbrink Tom Parke Sonja Zehetmayer Dario Zocholl
+	Highly Efficient Clinical Trials Simulator (HECT): Software application for planning and simulating platform adaptive trials	2019	Kristian Thorlund Shirin Golchi Jonas Häggström Edward J. Mills
+	Highly Efficient Clinical Trials Simulator (HECT): Software application for planning and simulating platform adaptive trials	2019	Kristian Thorlund Shirin Golchi Jonas Häggström Edward J. Mills
+ PDF Chat	POSC427 Platform Trials: A Path to Efficient Decision Making and Faster Drug Approvals for Health Technology Assessment Bodies	2022	N.E. Zannat M Zoratti Amruta Radhakrishnan MR Faulkner M. C. RUTHERFORD G. Tremblay
+	Adaptive Platform Trials: The Clinical Trial of the Future?	2017	Ariel Dora Stern Sarah Mehta
+	An Executive’s View of Value of Platform Trials	2018	David Reese Phuong Khanh Morrow
+ PDF Chat	Economic Evaluation of Cost and Time Required for a Platform Trial vs Conventional Trials	2022	Jay Park Behnam Sharif Ofir Harari Louis Dron Anna Heath Maureen O. Meade Ryan Zarychanski Raymond Lee Gabriel Tremblay Edward J. Mills
+	Platform Trials	2023	Jay Park J. Kyle Wathen Edward J. Mills
+	Platform Trials	2018	Ben Saville Scott Berry
+	How to Use and Interpret the Results of a Platform Trial	2022	Jay Park Michelle A. Detry Srinivas Murthy Gordon Guyatt Edward J. Mills
+	SIMPLE—A modular tool for simulating complex platform trials	2023	Elias Laurin Meyer Tobias Mielke Tom Parke Peter Jacko Franz Koenig
+	Collaborative Platform Trials to Fight COVID‐19: Methodological and Regulatory Considerations for a Better Societal Outcome	2021	Olivier Collignon Carl‐Fredrik Burman Martin Posch Anja Schiel
+ PDF Chat	Characteristics, Progression, and Output of Randomized Platform Trials	2024	Alexandra Griessbach Christof Schönenberger Ala Taji Heravi Viktoria Gloy Arnav Agarwal Tim Jonas Hallenberger Stefan Schandelmaier Perrine Janiaud Alain Amstutz Manuela Covino
+ PDF Chat	Statistical consideration when adding new arms to ongoing clinical trials: the potentials and the caveats	2021	Kim May Lee Louise Brown Thomas Jaki Nigel Stallard James Wason
+ PDF Chat	Uptake of the multi-arm multi-stage (MAMS) adaptive platform approach: a trial-registry review of late-phase randomised clinical trials	2022	Nurulamin M Noor Sharon Love Talia Isaacs Richard Kaplan Mahesh Parmar Matthew R. Sydes
+ PDF Chat	Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL	2023	Franz Koenig Cécile Spiertz Daniel Millar Sarai Rodríguez Núria Machín Ann Van Dessel Joan Genescà Juan M. Pericàs Martin Posch Adrián Sánchez‐Montalvá
+	CohortPlat: Simulation of Cohort Platform Trials for Combination Treatments	2021	Elias Laurin Meyer
+ PDF Chat	Next generation clinical trials: Seamless designs and master protocols	2024	Abigail Burdon Thomas Jaki Xijin Chen Pavel Mozgunov Haiyan Zheng Richard D. Baird

Works That Cite This (117)

Action	Title	Year	Authors
+	The Bayesian Time Machine: Accounting for temporal drift in multi-arm platform trials	2022	Benjamin R. Saville Donald A. Berry Nicholas Berry Kert Viele Scott Berry
+ PDF Chat	Controlling type I error rates in multi‐arm clinical trials: A case for the false discovery rate	2020	James Wason David S. Robertson
+	Comparison of response adaptive randomization features in multiarm clinical trials with control	2020	Kert Viele Benjamin R. Saville Anna McGlothlin Kristine Broglio
+	Allocation in platform trials to maintain comparability across time and eligibility	2023	Kert Viele
+ PDF Chat	Borrowing Concurrent Information from Non-Concurrent Control to Enhance Statistical Efficiency in Platform Trials	2023	Jialing Liu Chengxing Lu Ziren Jiang Demissie Alemayehu Lei Nie Haitao Chu
+	SIMPLE—A modular tool for simulating complex platform trials	2023	Elias Laurin Meyer Tobias Mielke Tom Parke Peter Jacko Franz Koenig
+	Adaptive Platform Trials in Stroke	2024	Elizabeth Lorenzi Amy Crawford Craig S. Anderson Bijoy K. Menon Xiaoying Chen Eva Mistry Pooja Khatri Jordan Elm Jonathan Beall Benjamin R. Saville
+	Adaptive platform trials: definition, design, conduct and reporting considerations	2019
+	Designing Clinical Trials That Accept New Arms: An Example in Metastatic Breast Cancer	2017	Steffen Ventz Brian M. Alexander Giovanni Parmigiani Richard D. Gelber Lorenzo Trippa
+	Multiplicity issues for platform trials with a shared control arm	2020	Xiaofei Bai Qiqi Deng Dacheng Liu

Works Cited by This (9)

Action	Title	Year	Authors
+	Bayesian Adaptive Methods for Clinical Trials	2010	Cody Hamilton
+ PDF Chat	Bayesian hierarchical modeling of patient subpopulations: Efficient designs of Phase II oncology clinical trials	2013	Scott Berry Kristine Broglio Susan Groshen Donald A. Berry
+ PDF Chat	The utility of Bayesian predictive probabilities for interim monitoring of clinical trials	2014	Benjamin R. Saville Jason T. Connor Gregory D. Ayers JoAnn Alvarez
+	The Platform Trial	2015	Scott Berry Jason T. Connor Roger Lewis
+	The Brave New World of clinical cancer research: Adaptive biomarker‐driven trials integrating clinical practice with clinical research	2015	Donald A. Berry
+ PDF Chat	Commentary on Hey and Kimmelman	2015	J. Jack Lee
+ PDF Chat	Are outcome-adaptive allocation trials ethical?	2015	Spencer Phillips Hey Jonathan Kimmelman
+ PDF Chat	Bayesian adaptive design for targeted therapy development in lung cancer — a step toward personalized medicine	2008	Xian Zhou Suyu Liu Edward S. Kim Roy S. Herbst J. Jack Lee
+	Commentary on Hey and Kimmelman	2015	Donald A. Berry