Type: Article
Publication Date: 2013-01-01
Citations: 0
DOI: https://doi.org/10.1155/2013/386058
e clinical trial, a prospective evaluation of the effect of interventions in humans under prespeci�ed conditions, is a standard and integral part of modern medicine.Many adaptive and sequential approaches have been proposed for clinical trials, which allow for modi�cations to an ongoing trial without undermining the validity and integrity of the trial.e application of adaptive and sequential methods in clinical trials has signi�cantly improved the �exibility, efficiency, therapeutic effect, and validity of such trials.is special issue describes state-of-the-art statistical research in adaptive and sequential methods and the application of such methods in clinical trials.It provides 1 review article and 5 research articles contributed by some of the leading experts in this �eld.e review article gives a comprehensive overview of the outstanding methodology in the current literature that is related to adaptive and sequential clinical trials, while each of the 5 research articles addresses speci�c critical issues in contemporary clinical trials, as summarized below.In the review paper "Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials," by Z. Chen et al., the most distinguished and applicable adaptive and sequential approaches, especially novel designs, are reviewed, compared, and contrasted according to the phase of clinical trial (phases I, II, and III) to which they are applied.e future directions of the related areas of research are also explored and discussed.e research article entitled "Exact group sequential methods for estimating a binomial proportion, " by Z. Chen
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