Medicine Pathology and Forensic Medicine

Historical and Scientific Studies

Description

This cluster of papers explores the intersection of medical serial killers, forensic toxicology, historical clinical chemistry, criminal poisoning, patient safety, healthcare regulation, and ethical considerations. It delves into cases like Shipman, explores the use of anonymity in healthcare, and discusses the development of forensic toxicology and surveillance photography. The papers also touch upon the historical milestones and discoveries that have shaped the toxicology sciences.

Keywords

Forensic Toxicology; Medical Chemistry; Serial Homicide; Anonymity in Healthcare; Criminal Poisoning; Patient Safety; Healthcare Regulation; Historical Clinical Chemistry; Surveillance Photography; Ethical Considerations

Does a failure to produce enjoyable prose ever indicate a failure to enjoy anal sex? If so, when? Let us consider the case of two colleagues with whom I happen … Does a failure to produce enjoyable prose ever indicate a failure to enjoy anal sex? If so, when? Let us consider the case of two colleagues with whom I happen to have had no intercourse whatsoever.
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor … Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The identification of the genes responsible for certain serious diseases and the development of tests for identifying carriers of those genes help to put the individuals concerned in the forefront … The identification of the genes responsible for certain serious diseases and the development of tests for identifying carriers of those genes help to put the individuals concerned in the forefront of ethical decisions. These decisions are unavoidable, especially when available knowledge and techniques have already been broadly disseminated. This article presents the case of a limb-girdle muscular dystrophy patient in Reunion Island who refuses to comprehend the lessons of genetics and to become part of the medical and associative networks that implement and diffuse that knowledge. His refusal is interpreted as the rejection of a form of agency and subjectivity, in which the individual is considered as an autonomous subject forced to choose between a number of pre-established options and responsible for the consequences of his choices. Using definitions of humanity and morality presented by François Jullien in his commentary on Mencius, the authors propose to consider that, by refusing, the patient is opting for a different form of morality and humanity. The article also shows how the interview situation constructs a situation that reduces the patient to silence.
It is hardly necessary for me to refer to my appreciation of the great honour conferred in asking me to give this lecture. It might be thought that the title … It is hardly necessary for me to refer to my appreciation of the great honour conferred in asking me to give this lecture. It might be thought that the title is more suited to a detective novel and that it was somewhat frivolous for the occasion! Curiously enough I hope that some of the points with which I shall deal to-day will make the path of would-be poisoners somewhat more thorny; and in a way there has been a little of the detective atmosphere about the research. My main theme is the biochemistry and physiology of the poison fluoroacetic acid; this is, as I think, the first instance of ‘lethal synthesis’ in the sense that fluoroacetic acid becomes lethal only when it has been transformed by the action of the tissue enzymes. It is the biochemistry which makes it lethal, the poison being a biochemical product of the tissue which is poisoned.
Many hospitals are experiencing an influx of patients who have made several suicide attempts through wrist slashing. A study was undertaken to learn the possible causes of such behavior. It … Many hospitals are experiencing an influx of patients who have made several suicide attempts through wrist slashing. A study was undertaken to learn the possible causes of such behavior. It suggested that the wrist slashers have a common behavior pattern stemming from early maternal deprivation and imbedded in inability to give and receive meaningful verbal communications. Therapy is directed at fostering more mature methods of giving and receiving love.
In 1880, Jules Cotard reported a clinical state he believed was a new type of agitated melancholia. A statistical analysis has been carried out of 100 cases of Cotard's syndrome … In 1880, Jules Cotard reported a clinical state he believed was a new type of agitated melancholia. A statistical analysis has been carried out of 100 cases of Cotard's syndrome to determine how this clinical concept has fared since its inception. In terms of clinical profile, no difference was found between men and women or between underlying diagnostic categories; age seemed to increase the likelihood of developing délire des négations. Depression was reported in 89% of subjects; the most common nihilistic delusions concerned the body (86%) and existence (69%). Anxiety (65%) and guilt (632) were also common, followed by hypochondriacal delusions (58%) and delusions of immortality (55). An exploratory factor analysis extracted 3 factors: psychotic depression, Cotard type I and Cotard type II. The psychotic depression factor included patients with melancholia and few nihilistic delusions. Cotard type I patients, on the other hand, showed no loadings for depression or other disease and are likely to constitute a pure Cotard syndrome whose nosology may be closer to the delusional than the affective disorders. Type II patients showed anxiety, depression and auditory hallucinations and constitute a mixed group. This new grouping cuts across the more traditional view and may have therapeutic implications. Authors, in general, have considered délire des négutions as a syndrome rather than a new disease and do not seem to support the view that the completeness of the syndrome is a function of presence or severity of depression. The view that délire des négutions refers only to the delusion of being dead has also curried little favour as it is likely to waste information.
Preface 1. From pharmacy to chemistry 2. Organic analysis and the Giessen Research School 3. Liebig and organic chemistry, 1820-40 4. Liebig and the British 5. Liebig and commerce 6. … Preface 1. From pharmacy to chemistry 2. Organic analysis and the Giessen Research School 3. Liebig and organic chemistry, 1820-40 4. Liebig and the British 5. Liebig and commerce 6. Liebig and the farmers: agricultural chemistry 7. Liebig and the doctors: animal chemistry 8. Liebig on toast: the chemistry of food 9. Liebig and London: the chemistry of sewage 10. Populariser of science: chemical letters 11. Philosopher of science: the Bacon Affair 12. Death and assessment Appendices Bibliography Index.
Robert A. Nye places in historical context a medical concept of deviance that developed in France in the last half of the nineteenth century, when medical models of cultural crisis … Robert A. Nye places in historical context a medical concept of deviance that developed in France in the last half of the nineteenth century, when medical models of cultural crisis linked thinking about crime, mental illness, prostitution, alcoholism, suicide, and other pathologies to French national decline.Originally published in 1984.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These paperback editions preserve the original texts of these important books while presenting them in durable paperback editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
We have recently shown in a series of papers<sup>1</sup>that alpha-dinitrophenol markedly augments metabolism in doses which are not demonstrably harmful. As this drug may have a number of important clinical … We have recently shown in a series of papers<sup>1</sup>that alpha-dinitrophenol markedly augments metabolism in doses which are not demonstrably harmful. As this drug may have a number of important clinical applications, it seems desirable to present a summary report of its pharmacologic and therapeutic effects, and to point out certain potential dangers in, and limitations to, its use. During the World War, dinitrophenol was called to the attention of French physicians by cases of poisoning from it in munitions factories. Only incomplete investigations of the actions of the compound were made at that time, as judged by published reports. Recently, Magne, Mayer, Plantefol and others<sup>2</sup>have extended or completed work begun some years previously but reported simultaneously with our entirely independent studies. We are in general agreement with them as to the main pharmacologic actions of the drug. The experimental studies have been extended by us and
Book Review| October 01 2009 Just Health: Meeting Health Needs Fairly Norman Daniels. Just Health: Meeting Health Needs Fairly. Cambridge: Cambridge University Press, 2008. 397 pp. $29.99 paper. Jacqueline L. … Book Review| October 01 2009 Just Health: Meeting Health Needs Fairly Norman Daniels. Just Health: Meeting Health Needs Fairly. Cambridge: Cambridge University Press, 2008. 397 pp. $29.99 paper. Jacqueline L. Colby Jacqueline L. Colby Search for other works by this author on: This Site Google J Health Polit Policy Law (2009) 34 (5): 839–846. https://doi.org/10.1215/03616878-2009-027 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Jacqueline L. Colby; Just Health: Meeting Health Needs Fairly. J Health Polit Policy Law 1 October 2009; 34 (5): 839–846. doi: https://doi.org/10.1215/03616878-2009-027 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsJournal of Health Politics, Policy and Law Search Advanced Search The text of this article is only available as a PDF. Duke University Press2009 Article PDF first page preview Close Modal You do not currently have access to this content.
The Twentieth International Red Cross Conference, meeting in Vienna in 1965, proclaimed the “fundamental principles upon which Red Cross action is based”. Since that time, at every Conference, the representatives … The Twentieth International Red Cross Conference, meeting in Vienna in 1965, proclaimed the “fundamental principles upon which Red Cross action is based”. Since that time, at every Conference, the representatives of the Red Cross world rise to their feet to hear the solemn reading of those principles. The principles, however, have not yet been the subject of any commentary. The fact is that the book “ Les principes de la Croix-Rouge ”, the source of the Vienna text, antedated the official version which, while being close to the model, was not identical with it. The book referred to was indeed a complete work, of a somewhat scientific character, and not a terse commentary designed to serve the general public.
Criminologists continue to debate fundamental issues about the nature of their work. Some of the issues were built into the field by the criminal anthropologists who founded it a century … Criminologists continue to debate fundamental issues about the nature of their work. Some of the issues were built into the field by the criminal anthropologists who founded it a century ago. By examining the work of major American criminal anthropologists—a nearly forgotten group—one can identify the origins of three enduring problems: criminology's difficulties in (1) establishing its disciplinary boundaries; (2) defining its methods: and (3) deciding whether its primary goal is crime control or the production of knowledge with no immediate use‐value. The study of criminology's roots in criminal anthropology cannot settle these debates, but it can put them in historical perspective and clarify their substance.
Abstract Neurologic diseases (Vata rogas, Sanskrit) and the pharmacologic treatment of them were described in the ancient Indian medical system—Ayurveda. This article explores paralysis agitans, which was described under the … Abstract Neurologic diseases (Vata rogas, Sanskrit) and the pharmacologic treatment of them were described in the ancient Indian medical system—Ayurveda. This article explores paralysis agitans, which was described under the name Kampavata. Mucuna pruriens (Atmagupta, Sanskrit), which contains levodopa, was used in the treatment of Kampavata. Existence of paralysis agitans prior to the industrial revolution is not just of historical interest, but would also suggest that under the hypothesis of exposure to environmental toxins as a possible cause of paralysis agitans, natural organic compounds with worldwide distribution should also be considered.
This book presents research on the history of criminology from the late eighteenth to the mid-twentieth century in Western Europe (Austria, Britain, France, Germany, Italy) and in Argentina, Australia, Japan, … This book presents research on the history of criminology from the late eighteenth to the mid-twentieth century in Western Europe (Austria, Britain, France, Germany, Italy) and in Argentina, Australia, Japan, and the United States. Approaching the history of criminology as a history of science and practice, the essays examine the discourse on crime and criminals that surfaced as part of different discourses and practices, including the activities of the police and the courts, parliamentary debates, media reports, as well as the writings of moral statisticians, jurists, and medical doctors. In addition, the book seeks to elucidate the relationship between criminological discourse and politics, society, and culture by providing a comparative study of the worldwide reception of Cesare Lombroso's criminal-anthropological ideas.
ABSTRACT Nile blue, introduced by Lorrain Smith for distinguishing between neutral fats (triglycerides) and fatty acids, was considered by Lison to be of no histochemical value except that the red … ABSTRACT Nile blue, introduced by Lorrain Smith for distinguishing between neutral fats (triglycerides) and fatty acids, was considered by Lison to be of no histochemical value except that the red coloration was specific for lipoids in general. This conclusion was based principally on Lison’s own researches, and in part on those of Kaufmann and Lehmann. Reinvestigation has shown that some of Kaufmann and Lehmann’s results are of doubtful value and all require careful interpretation, but in general these and other results lead to the conclusion that nile blue can be used to distinguish neutral lipoids (esters and hydrocarbons) from acidic lipoids (phospholipines and acids). Cholesterol is not detected. A method for using both the oxazine and oxazone of nile blue is described, which has greater sensitivity to acidic lipoids.
Robert A. Nye places in historical context a medical concept of deviance that developed in France in the last half of the nineteenth century, when medical models of cultural crisis … Robert A. Nye places in historical context a medical concept of deviance that developed in France in the last half of the nineteenth century, when medical models of cultural crisis linked thinking about crime, mental illness, prostitution, alcoholism, suicide, and other pathologies to French national decline. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Andre Gide, renowned French essayist, novelist, and playwright, was also a homosexual apologist whose sexuality was central to the whole of his literary and political discourse. This book by Patrick … Andre Gide, renowned French essayist, novelist, and playwright, was also a homosexual apologist whose sexuality was central to the whole of his literary and political discourse. This book by Patrick Pollard—the first serious study of homosexuality in Gide’s theater and fiction—analyzes his ideas and traces the philosophical, anthropological, scientific, and literary movements that influenced his thought. Pollard begins by discussing Corydon , a defense of pederasty that Gide felt was his most important book. He then provided a historical and analytical survey of books that contributed to Gide’s perception of homosexuality, including works on philosophy, social theory, natural history, and medicolegal questions. Pollard goes on to investigate works of fiction—ancient and modern, European and Oriental—in which Gide saw homosexual elements. He concludes by considering the homosexual themes in Gide’s own works, analyzing the ways that Gide constantly tried to resolve conflicts between nature and culture, hypocrisy and honesty, corruption and sound moral judgment, anomaly and conformity, and sexual freedom and religious constraint. The book provides a new perspective on Gide’s work, a reconstruction of the moral and intellectual climate in Europe at the beginning of the twentieth century, and a substantial contribution to the cultural history of homosexuality.
La proposition de la Section clinique que Lacan fait en 1977 est la conclusion la plus aboutie d’un dispositif où le savoir analytique est accessible à un groupe. Avec la … La proposition de la Section clinique que Lacan fait en 1977 est la conclusion la plus aboutie d’un dispositif où le savoir analytique est accessible à un groupe. Avec la pratique de la présentation, Lacan ne perpétue pas la tradition médicale mais il va la subvertir. Historiquement Lacan reconnaît l’importance de la naissance d’une nouvelle clinique comme condition pour l’émergence du discours analytique. Cet article, veut montrer un point de convergence, malgré les différences entre Michel Foucault et Jacques Lacan. Lacan fera de nombreuses allusions à Naissance de la clinique , des années après sa publication, il a été un lecteur rigoureux et constant de l’œuvre de Foucault, mais le seul livre auquel il a fait référence de manière explicite dans ses Écrits est Naissance de la clinique .
Abstract On the broad outlines of that analysis the great Victorian moral philosophers John Stuart Mill, Herbert Spencer,2 and Henry Sidgwick3-all seem agreed. It is the place of society to … Abstract On the broad outlines of that analysis the great Victorian moral philosophers John Stuart Mill, Herbert Spencer,2 and Henry Sidgwick3-all seem agreed. It is the place of society to stop us from doing things that will harm others; it is not the place of society to stop us from doing things that will harm no one but ourselves. In Mill’s classic formulation: the sole end from which mankind are warranted, individually or collectively, in interfering with the liberty of action of any of their number is self-protection.... The only purpose for which power can be rightfully exercised over any member of a civilized community, against his will, is to prevent harm to others. His own good, either physical or moral, is not a sufficient warrant. He cannot rightfully be compelled to do or forbear because it will be better for him to do so, because it will make him happier, because, in the opinions of others, to do so would be wise or even right. These are good reasons for remonstrating with him, or reasoning with him, or persuading him, or entreating him, but not for compelling him, or visiting him with any evil in case he do otherwise The only part of the conduct of any one, for which he is amenable to society, is that which concerns others. In the part which merely concerns himself, his independence is, of right, absolute. Over him self, over his own body and mind, the individual is sovereign.
Abstract Chapter 1 situates live facial recognition (LFR) in the context of law enforcement’s long history of engagement with both technology and biometric identification techniques. Originating as far back as … Abstract Chapter 1 situates live facial recognition (LFR) in the context of law enforcement’s long history of engagement with both technology and biometric identification techniques. Originating as far back as the 1880s and Parisian detective Alphonse Bertillon’s innovative use of fingerprinting and custody images, policing has consistently embraced innovation. However, recent years have seen dramatic technological advancement, and by extension an expansion in law enforcement surveillance capability. Advanced computational innovations—such as AI-driven decision-making and algorithmic information management processes—have made detailed insight into individuals’ day-to-day activities, attributes, and behaviours increasingly possible, rendering the invisible visible and available for analysis. Facial recognition technology sits squarely in this process. Advances in AI-driven convolutional neural networks have transformed a once niche, gimmicky, and poorly performing technology into a viable and potentially powerful tool of police surveillance. Uses of LFR sit at the intersection of these processes and debates. In addition to offering radically new surveillance capabilities, LFR technology operates in different ways to existing surveillance architectures and subtly alters several longstanding aspects of policework, including the application of discretion and formulation of suspicion. Moreover, public uses of this technology constitute a meeting point where issues of citizenship, rights, law enforcement, and digital society intersect.
Abstract Chapter 7 analyses the deployment of live facial recognition through unique empirical examination of authorization procedures, planning practices, operational briefings, uses of police intelligence, and the assembly and classification … Abstract Chapter 7 analyses the deployment of live facial recognition through unique empirical examination of authorization procedures, planning practices, operational briefings, uses of police intelligence, and the assembly and classification of data to construct suspect databases. The analysis reveals how surveillance deployments are shaped by the affordances of this technology and belief in its capability, with intelligence often used in instrumental ways to support such decisions. Associated practices become further legitimized through discourses that reify the potential of technology and valorize partial information as ‘actionable intelligence’. Additional ambiguities are revealed during the assembly of dispersed data and its inconsistent classification during the construction of suspect databases. Together, these practices reveal a paradox whereby perceived certainties brought about by technology become mediated through ambiguous and uncertain operational environments. Considered together, these practices hold profound implications for the conduct of police surveillance.
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À l’évidence des faits s’attache l’évidence de la qualification. Cette formule sied particulièrement bien à la solution rendue par la chambre des appels correctionnels de Grenoble, dans un arrêt en … À l’évidence des faits s’attache l’évidence de la qualification. Cette formule sied particulièrement bien à la solution rendue par la chambre des appels correctionnels de Grenoble, dans un arrêt en date du 11 juillet 2024 relatif à une affaire de violences involontaires suite à une agression commise par un chien.
Followers and admirers of L'Arche, an international network of communities for adults with intellectual disabilities, were shocked and saddened to learn of allegations of sexual abuse against its founder, Jean … Followers and admirers of L'Arche, an international network of communities for adults with intellectual disabilities, were shocked and saddened to learn of allegations of sexual abuse against its founder, Jean Vanier, that surfaced in 2020. This article examines aspects of L'Arche's history as well as its discourse and practices that may have contributed to the perpetration and hiding of abuse that took place over decades. Drawing from critical interdisciplinary scholarship, I discuss the abuse that happened in L'Arche not as a historical aberration but as an example of the spectrum of care and violence that exists in all caregiving situations. Further, I consider what this story reveals about the ways in which people with intellectual disabilities, and the supports they need, continue to be interpreted and understood, and what this means moving forward.

Multiple drugs

2025-05-30
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Au cours des vingt dernières années, la notion d’incorporation s’est imposée dans les sciences biomédicales. Comment en sommes-nous venus à penser les formes de vie biologiques comme résultant d’une incorporation … Au cours des vingt dernières années, la notion d’incorporation s’est imposée dans les sciences biomédicales. Comment en sommes-nous venus à penser les formes de vie biologiques comme résultant d’une incorporation des normes sociales ? Cette histoire épistémologique et politique de l’épidémiologie sociale entend répondre à cette question. Elle vise plus généralement à repenser les catégories du normal et du pathologique au prisme d’une approche socio-médicale.
Abstract Pregnancy encompasses core socio-political issues: kinship, demography, religion, gender and more. In any society, the ontology of the pregnant body and the embryo-fetus holds core existential concerns. Is a … Abstract Pregnancy encompasses core socio-political issues: kinship, demography, religion, gender and more. In any society, the ontology of the pregnant body and the embryo-fetus holds core existential concerns. Is a pregnant body one or two beings? When does personhood begin? Yet pregnancy is still a marginal topic in archaeology and its onto-political consequences have scarcely been raised. It would be ludicrous to claim that pregnancy or childbirth is part of the grand narratives of prehistory. Also in scholarship centring theoretical perspectives on the body and personhood the pregnant body is absent . This article poses fundamental questions of the body-politics of pregnancy. We develop concepts from material feminism, medical ethics and philosophy to interrogate pregnancy and provide a case study to demonstrate how these concepts can work in practice from the Viking Age. The questions posed, however, are not limited to the Viking period. Our overall objective is to centre pregnancy as a philosophical and political concern in archaeology writ large . We develop new thinking and language to this end, which can be used to examine the politics of pregnancy in other periods and regions. Ultimately, we discuss the absence-making of pregnant bodies from our sources as well as from archaeological discourse.
Alien hand syndrome (AHS) is a rare neurological condition characterized by involuntary and uncontrollable movements of an upper limp. Based on clinical presentation and affected brain region, AHS has three … Alien hand syndrome (AHS) is a rare neurological condition characterized by involuntary and uncontrollable movements of an upper limp. Based on clinical presentation and affected brain region, AHS has three variants: frontal, callosal and posterior. Treatment of AHS is based on anecdotal reports and includes clonazepam, botulinum toxin injections, cognitive behavioural therapy, visuospatial coaching, distracting tasks and mirror box therapy. In this case report, we present two patients admitted to rehabilitation with AHS after an ischaemic stroke. One of them received mirror box therapy.

BEN LOMOND

2025-05-01
La mise en place de systèmes de vidéosurveillance automatisée suscite de nombreuses controverses quant au rapport entre le coût financier et démocratique de son déploiement et sa réelle utilité. Notre … La mise en place de systèmes de vidéosurveillance automatisée suscite de nombreuses controverses quant au rapport entre le coût financier et démocratique de son déploiement et sa réelle utilité. Notre article vise à contribuer à ces questionnements en étudiant la fabrication et le déploiement de deux systèmes de vidéosurveillance automatisée : AIView qui est appliqué à la vidéosurveillance des magasins et AICity qui concerne la surveillance de l’espace public. L’enquête repose sur une étude de bout en bout des systèmes d’IA auprès des acteurs qui participent à sa fabrication et à son fonctionnement : data scientists, travailleurs de la donnée et utilisateurs du système. Nous contribuons à la littérature en montrant que la surveillance automatique s’appuie toujours sur des médiateurs humains. En effet, pour fonctionner les modèles s’appuient à la fois sur le travail d’annotateurs de données, qui lui fournissent une vision simplifiée du réel sous la forme de jeux de données, et sur les vidéo-opérateurs qui interprètent les sorties des systèmes intelligents. Ces deux groupes de travailleurs permettent une adaptabilité en temps réel du système de surveillance aux besoins émergeant de situations complexes.
The advent of experimental medicine in the early nineteenth century marked a crucial turning point in history of medicine. Historians unanimously recognize François Magendie (1783-1855), a physician and physiologist, as … The advent of experimental medicine in the early nineteenth century marked a crucial turning point in history of medicine. Historians unanimously recognize François Magendie (1783-1855), a physician and physiologist, as a pioneer of experimental medicine. Despite his significance, research on Magendie’s achievements and contributions remains limited. This scarcity stems from conflicting evaluations of Magendie's experimental medicine. On one hand, some claim that Magendie avoided hypotheses and simply accumulated individual facts. On the other hand, others argue that he implicitly used hypotheses. These differing views traces back to his disciple Claude Bernard (1813-1878), who believed it was impossible to conduct experiments without hypotheses. If Magendie was a pioneer of experimental medicine, then he must have had hypotheses as well. However, interpretations of his viewpoint on hypotheses vary. This paper aims to clarify this issue. By examining contemporary evaluations of physiology during Magendie’s time, the concept of collaborative research with chemist Antoine-Laurent Lavoisier (1743-1794), and the laboratory environments where these ideas were realized, this study finds new insights into Magendie’s approaches to experimental medicine. Magendie was extremely cautious in formulating his own hypotheses, but he often designed experiments based on the hypotheses of other physiologists. His criticism of Bichat exemplifies this tendency. The conclusions derived from this study are as follows: first, there is a need to reconsider the current historical understanding of Magendie's experimental medicine; second, the history of early nineteenth century medicine, particularly in the context of large-scale collaborative research, requires a different analytical approach than that applied to earlier periods.