Medicine › Surgery

Biomedical and Chemical Research

Works Count: 95773

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This cluster of papers covers a wide range of topics in medical science and healthcare, including anaesthesia, clinical leadership, chemistry, neurology, physiology, cancer management, healthcare reform, and the use of medical gases. The papers discuss advancements in medical treatments, diagnostic techniques, and healthcare management.

Keywords

Anaesthesia; Medical Gases; Clinical Leadership; Chemistry; Neurology; Physiology; Thermodynamics; Oxygen Consumption; Cancer Management; Healthcare Reform

Der aphasische Symptomenkomplex

1974-01-01

Carl Wernicke

Über humorale Übertragbarkeit der Herznervenwirkung

1924-12-01

O. Loewi , E. Navratil

Die komplexometrische Titration

1955-01-01

G. Schwarzenbach

Allgemeine Anatomie und Physiologie des Nervensystems

1903-01-01

Albrecht Bethe

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Die Elementarorganismen und ihre Beziehungen zu den Zellen

1894-12-31

Richard Altmann

Physiologie des Menschen

2007-01-01

Robert F. Schmidt , Florian Läng

Zur Lehre von der Wirkung der Salze

1888-02-01

Franz Hofmeister

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Handbuch der Normalen und Pathologischen Physiologie

1927-01-01

A. Bethe , G. v. Bergmann , G. Embden +1 more

Proposed supplements and amendments to ‘A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects’, the Rechtschaffen & Kales (1968) standard

2001-06-01

Tadao Hori , Yoshio Sugita , Einosuke Koga +7 more

In 1967, the Association for the Psychophysiological Study of Sleep (APSS) chartered a committee of sleep researchers to establish a standard system for visually scoring stages of sleep. The Committee’s … In 1967, the Association for the Psychophysiological Study of Sleep (APSS) chartered a committee of sleep researchers to establish a standard system for visually scoring stages of sleep. The Committee’s terminology and scoring system (edited by Alan Rechtschaffen and Anthony Kales, co-Chairpersons of the Committee) were quickly adopted after its 1968 publication under the auspices of the UCLA Brain Information Service as ‘A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects’. The manual and its recommendations have been well accepted and the system has spread across the world. The proposal to standardize recording techniques and scoring criteria was intended to increase the comparability of results reported by different investigators. Researchers who have applied the system correctly have increased the reliability of their sleep stage scoring. In the several decades since its publication, however, a number of serious areas of unreliability in the 1968 standard scoring system have been identified. In particular, researchers developing computer-based automatic sleep staging systems have encountered numerous vague and ambiguous areas in the current standard. At the 15th Annual Meeting of the Japanese Society of Sleep Research (JSSR) in 1990, Terashima’s report from the Japanese Conference for Sleep Analysis emphasized the need to re-examine the definitions of sleep stages when developing computer staging systems based on the standard scoring system. The results of multiple comparisons among institutes and laboratories using methods for automated sleep staging based on the standard scoring system were unexpectedly poor. The lowest level of congruence between automation and records staged visually using the 1968 standard system was found for Stage 1 sleep, with the second worst agreement (still less than 70%) for sleep Stages 3 and 4. To increase both the within- and between-researcher agreement in sleep stage identification and to foster the development of computer algorithms for automatic analyses of sleep, a need for additional definitions was recognized. In 1991, the Subcommittee for Automatic Sleep Staging (SASS) was formed by the JSSR. The Subcommittee comprised 53 investigators and seven project leaders selected for their skill in scoring sleep records: S. Sugita (Chair), M. Okawa (co-Chair), T. Kobayashi, T. Hori, A. Miyasita, S. Shirakawa and Y. Atsumi. In 1995, based on their 5 year discussions, the Subcommittee proposed supplementary definitions and amendments for the Standard Scoring System to the JSSR. These proposals were reported in the JSSR Newsletter (1996; No. 13, February 1, pages 5–13). In 1997, at its 22nd Annual Meeting, the JSSR restructured the SASS to form the Sleep Computing Committee (SCC). The SCC working group has now formalized Supplements and Amendments to the Standard Scoring System based upon the 1995 SASS proposals. The Committee has met several times for discussion and to test their new definitions using carefully selected representative polysomnographic recordings. The final JSSR Sleep Computing Committee proposals have been published in Japanese as the ‘Learning Manual of PSG Chart: Polysomnogram, Sleep Stage Scoring, Interpretation’. The Committee has now prepared the English language version of their proposals for evaluation and empirical testing by sleep researchers all over the world. The JSSR’s proposals to supplement and amend the currently used criteria for sleep staging (A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects, Rechtschaffen A, Kales A (eds). BIS/BRI University of California, Los Angeles, 1968; hereafter, the ‘standard criteria (SC)’) are detailed below. When research purposes are not met by the SC, different movement time criteria may be used. However, in such cases, the modified criteria should be clearly stated and the degrees of modification should not exceed those in the following examples. MT is judged following the SC, with the addition of scoring parts of the recording with higher muscle tones and degrees of artifact as ‘gross movement’ or ‘movement with duration more than 50% of an epoch’, and the number of such segments is reported. Even when an epoch fulfils the SC definition of MT, the epoch may still be scored as a stage of sleep using additional criteria (below). In this case, an SC-defined epoch of MT can simultaneously be defined as an epoch of sleep and a body movement epoch. Examples of criteria: (i) MT epoch is scored as the same stage as the preceding epoch and (ii) MT epoch is scored as the same stage as the following epoch. The following supplementary definitions are used for scoring a transition from stage wake to Stage 1 sleep. Stage 1 is not necessarily defined as a sleep onset (sleep onset is defined below). Alpha waves are electroencephalographic waves with a frequency of 8 Hz or more but less than 13 Hz. A vertex sharp wave is a sharp waveform distinguished from background activities at or near Cz (C3, C4), with an amplitude of 75 μV or greater, and with a frequency of at least 5 Hz but no more than 14 Hz. Slow eye movements (SEM) can be difficult to detect in recordings that were not made using long time constants. The following definitions are considered to apply for recordings made under recommended conditions. Slow eye movements waveforms do not manifest saccade-like sharp, abrupt, movements. Rather, SEM are smooth sinusoidal eye movements with amplitudes of 100 μV or more, and 10 s or less in duration. Time constant: Longer time constants of 1.5 s or more are recommended to minimize deformations of SEM signals and to enhance the detection of SEM. Amplification: Amplification of 200 μV/5 mm is recommended. This amplification allows observation of subtle eye movements without appreciably increasing the likelihood of signals saturating the amplifier. Derivation: Monopolar recordings from both outer canthi are recommended to distinguish eye movements from contamination such as superimposition of electroencephalographic (EEG)waveforms. For subjects whose central EEG alpha waves during resting wakefulness occupy less than 50% of the analysis epoch when the eyes are closed, one of the following criteria should be used to judge Stage 1 sleep. When using these exception criteria, the resting wake EEG should be recorded both before bedtime and after awakening from all-night sleep recording along with observations to confirm that subjects are behaviorally awake. In subjects whose occipital EEG alpha activity occupy more than 50% of the analysis epoch during wakefulness with eyes closed, SC should be applied. Electroencephalogram of various frequencies but less than 8 Hz and 20 μV or more in amplitude, which is considered as EEG, suggesting lower vigilance level comparing resting wake with eyes closed condition, occupies more than 50%. In the absence of true alpha band activity, alpha-like activity in EEG frequencies below 8 Hz may be used to suggest lower vigilance levels when it is of 20 μV or greater amplitude, increases during resting wakefulness with the eyes closed, and occupies 50% or more of an epoch. When the preceding criteria (2) are applied, confirmation of SEM activity is also recommended. The following supplementary definitions of the K-complex should be considered. The K-complex waveform begins with the abrupt onset of a negative sharp wave, which is immediately followed by a high amplitude positive slow wave. Polyphasic (notched) negative-positive waves are sometimes observed just before the onset of the negative K-complex sharp wave. The duration of a K-complex must be longer than 0.5 s. Its peak-to-peak amplitude must be greater than 200 μV. Waveforms must be visually distinct from background EEG activities; and a waveform should not be identified as a K-complex if it occurs within 5 s preceding or following high voltage delta waves (defined below). The K-complex waveform may or may not be accompanied by sleep spindle activity (defined below). Termination of a K-complex is identified by the peak of a trailing negative wave, which follows the major positive component, neglecting other overlapping waves (Fig. 1). Sleep spindles are defined as trains of 12–16 Hz waves of 10 μV or greater amplitude, composed of at least six consecutive waves, or a train duration longer than 0.5 s. The appearance of the waveform train is not specified in the definition (i.e. a ‘spindle’ shape is not a requirement for identification as a sleep spindle). Although the mean frequency of a single train of waves can be used as a single descriptor for identified sleep spindles, its use must be clearly reported. Similarly, if a different amplitude threshold is used to identify sleep spindle activity, the threshold value must be clearly reported. Onset and termination of K-complex Sleep onset may be defined as necessary for research purposes, but should include the first epoch scored as one of the standard sleep Stages (1, 2, 3, 4, or REM) after the lights are darkened or a subject goes to bed. Researchers must report their definition of sleep onset. Researchers are expected to specify the sleep stage criteria used for the judgement of sleep onset, including all criteria for the duration of sleep stage(s), its (their) duration, and the time course of sleep etc. as in the following examples. In this example, the first epoch judged as one of the sleep stages is defined to be sleep onset. However, if the first stage is Stage 1, the epoch can be judged as sleep onset only if it is followed by consecutive epochs of sleep stages 2, 3, 4 or REM. In this example, the first epoch judged as one of the sleep stages is defined to be sleep onset. However, if the first stage is Stage 1, the epoch is judged as sleep onset on the condition that Stage 1 or the other stages continue for a specific length of time (e.g. 3 or 5 min). In this example, the first epoch judged as sleep Stages 2, 3, 4, or REM is defined to be sleep onset. (A definition to attach importance on the appearance of Stage 2.) In this example, the first epoch judged as sleep Stages 2, 3, 4, or REM is defined to be sleep onset. However, the epoch is judged as sleep onset on the condition that sleep Stages 2, 3, 4 or REM, follows for a specific duration (e.g. 3 or 5 min). The expressions of ‘Stage 1’ or ‘Stage 2’ in the example definitions can be modified to use ‘vertex sharp wave’ or ‘sleep spindle’ criteria as desired. If slow waves with frequencies below 2 Hz and with amplitudes greater 75 μV occupy between 20 and 50% of an epoch, that epoch is judged as Stage 3 sleep. If the slow waves occupy more than 50% of an epoch, that epoch is judged as Stage 4 sleep. However, because these definitions do not contain any descriptions of complex composite waveforms, it can often be difficult to judge Stages 3 and 4 under the SC. We add the following supplements to the definition of high amplitude slow waves given above. (i) When the combined period of two contiguous EEG waveforms is 0.5 s or longer (i.e. the frequency of the composite wave is 2 Hz or lower), that wave complex can be scored as one slow wave if the amplitudes of the two waves satisfy the requirement B ≥ A/2 (Fig. 2). (ii) When fast waves appear superimposed on a slow wave, the amplitude of the slow wave is still measured from peak-to-peak, including the superimposed waves. (iii) The onset of an individual slow wave must follow a trough satisfying the requirement B ≤ A/2 (Fig. 3). When bursts of slow wave activity precede or accompany an arousal response or high amplitude EMG (e.g. body movements), those bursts should not be considered slow waves for EEG stage scoring, but as one form of the arousal response. Such portions of a record should be considered part of the preceding or following epoch when stage scoring. Furthermore, the terms ‘movement arousal’ or ‘EEG arousal’ are recommended over the general term ‘arousal response’, following the definition of American Sleep Disorders Association (EEG arousal: scoring rules and examples. Sleep 1992; 15: 173–184). The same time constant, gain, electrode placements and montage can be used to record both SEM and REM. The REM waveform must appear as a saccadic movement, with rapid changes in angular velocity at the onset and termination of eye movement. Since small eye movements often appear during the transitions to and from REM sleep, a low amplitude criterion of 40 μV or greater (1 mm pen deflection under above-mentioned recording condition) is recommended. In recordings at 15 mm/s (or the equivalent digital display), REM activity should be identifiable as a 45° or greater angular departure from the baseline. Researchers should specifically report any modifications to the above-mentioned criteria. A twitch is defined as a skin-recorded EMG discharge with duration shorter than 0.5 s, or the EMG discharge accompanying the contraction of a single muscle unit. The term ‘these transient changes may be disregarded’ in the standard manual (p. 8) is ambiguous. Therefore, the muscle activities satisfying the above-mentioned definition of twitch may be disregarded, while a transient increase in tonic EMG not satisfying the definition may be regarded as a sign of movement arousal. Rechtschaffen and Kales (1968) discussed the difficulty of identifying the onset of REM sleep: A special case frequently arises where a movement arousal interrupts the continuity of stage REM, the mental-submental EMG quickly reverts to the stage REM level following the movement arousal, the EEG remains relatively low voltage, mixed frequency, and there is a resumption of REMs or change to stage 2 one or more epochs following the movement arousal. The problem is whether to score the interval following the movement arousal and the resumption of REMs or change to stage 2 as stage 1 or stage REM. (p.10, Part C). The general guidelines for distinguishing between Stage 1 and stage REM support little more than scorer judgement. The following partially modified guidelines have been arranged to aid the discrimination of Stage 1 from REM sleep. The following cases justify scoring as stage 1: (i) epochs follow long or intense movement arousals; (ii) epochs contain slow eye movements; (iii) epochs contain persisting alpha activity following a movement arousal; (iv) epochs contain well-formed vertex spikes; (v) epochs contain waveforms similar to, but not fulfilling the definitions of sleep spindles or K-complexes. Such cases may be considered as supporting evidence that the interval between the movement arousal and unambiguous Stage 2 or REM has been Stage 1. The following case justifies scoring as stage REM: (i) epochs contain well-formed saw-tooth waves. The following definitions of sleep parameters frequently used in sleep science and sleep medicine are listed for reference. Total recording time (TRT): The duration of time from the start to the end of a recording. Time in bed (TIB): The duration of time from ‘lights out’ to final awakening. Total sleep time (TST): The amount of actual sleep time in a recording. Sleep efficiency (SE): The ratio of total sleep time to time in bed (i.e. (TST ÷ TIB) × 100). Sleep period time (SPT): The duration of time from sleep onset to final awakening. Time spent in each of the sleep stages based on total recording time (TRT). TS1: Time spent in Stage 1. TS2: Time spent in Stage 2. TS3: Time spent in Stage 3. TS4: Time spent in Stage 4. TSR: Time spent in stage REM. Percentage of the sleep stages. (i) Percentage of the sleep stages based on sleep period time (SPT). %SW: Percentage of stage W. %S1: Percentage of Stage 1. %S2: Percentage of Stage 2. %S3: Percentage of Stage 3. %S4: Percentage of Stage 4. %SR: Percentage of stage REM. (ii) Percentage of the sleep stages based on total sleep time (TST). %S1: Percentage of Stage 1. %S2: Percentage of Stage 2. %S3: Percentage of Stage 3. %S4: Percentage of Stage 4. %SR: Percentage of stage REM. Wake time after sleep onset (WASO), intermittent awakening: The total time spent awake during sleep period time (SPT). Number of arousals: The number of arousals occurring in sleep period time (SPT). Number of stage shifts: The number of occasions of sleep stages shifting from one to another. Sleep latency: The duration of time from ‘lights out’, or bedtime, to the onset of sleep. REM sleep latency: The interval from sleep onset to the first appearance of stage REM sleep in a recording. REM activity: REM activity is identified as one or more REM in a unit of time and often expressed as the total number of such units. REM density: REM density is a function that expresses the frequency of eye movements per unit of time during stage REM. Number of REM episodes: The number of REM episodes that appear during sleep period time. If REM sleep continues with interruptions by wake or other sleep stages, such REM episodes are considered as a single REM episode when the interruption is less than 15 min. Sleep cycle: The first sleep cycle is the period from sleep onset to the end of the first REM sleep episode. Later sleep cycles are defined as the periods from the end of a REM sleep episode to the end of the subsequent REM sleep episode. REM sleep interval: The REM sleep interval is the interval between the end of a REM sleep episode and the beginning of the subsequent REM sleep episode. Time awake is generally excepted from the interval.

Physiologische und pharmakologische Versuche über die Dünndarmperistaltik

1917-06-01

Paul Trendelenburg

Remarks on a Case of Sudden Death in Ovariotomy While the Patient was under the Influence of Chloroform

1870-02-26

James Young Simpson

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HANDBUCH DER NEUROLOGIE

1912-06-01

M. Lewandowsky

Über die Richtung und die manifeste Grösse der Potentialschwankungen im menschlichen Herzen und über den Einfluss der Herzlage auf die Form des Elektrokardiogramms

1913-03-01

W. Einthoven , G. Fahr , A. de Waart

Lehrbuch der Allgemeinen Chemie

1893-05-01

J. W. Rodger

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Tietz Textbook of Clinical Chemistry

1994-08-24

Dávid

For years and through two editions, Tietz'sFundamentals of Clinical Chemistryserved as one of the major references in the field. In 1986, a closely related book, the first edition ofTextbook of … For years and through two editions, Tietz'sFundamentals of Clinical Chemistryserved as one of the major references in the field. In 1986, a closely related book, the first edition ofTextbook of Clinical Chemistry, was published, followed by the third edition ofFundamentals of Clinical Chemistryin 1987. The major difference between these two versions—TextbookandFundamentals—lies in the discussion of pathophysiology found inTextbook, whileFundamentalsretained a more analytical laboratory- and methods-oriented approach. Eight years later and with the second edition of theTextbook, Dr Tietz has passed his editorship to two new and very capable successors. Although a good number of the chapter authors have changed, the book retains many of its important characteristics. In the new edition ofTextbook, the editors have made some minor revisions in organization. The 20 chapters of the previous edition have been expanded to 41, and the book

Ueber die Nerven der menschlichen Haut

1868-09-01

Paul Langerhans

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Über quantentheoretische Umdeutung kinematischer und mechanischer Beziehungen

1985-01-01

W. Heisenberg

Ueber die Abhängigkeit der Capillaritäts‐Constanten des Alkohols von Substanz und Gestalt des benetzten festen Körpers

1863-01-01

Ludwig Wilhelmy

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Ueber die bewegende Kraft der Wärme und die Gesetze, welche sich daraus für die Wärmelehre selbst ableiten lassen

1850-01-01

R. Clausius

Über die Adsorption in Lösungen

1907-10-01

H. Freundlich

Über die Bestimmung kleiner Pentosemengen, insbesondere in Derivaten der Adenylsäure

1939-01-01

Wanda Mejbaum

[Mechanical properties of living tissues].

1986-08-01

Mizuto Sato

Handbuch der Normalen und Pathologischen Physiologie

1925-01-01

A. Bethe , G. Embden , G. v. Bergmann +7 more

Handbuch der Physiologie des Menschen

1909-01-01

Wilibald A. Nagel

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Manual der OSTEOSYNTHESE

1992-01-01

M. Müller , M. Allgöwer , R. Schneider +1 more

Progress in Allergy.

1949-01-01

P. Kallós

Zur Lehre von der Wirkung der Salze

1888-08-01

Franz Hofmeister

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Lehrbuch der Anatomie des Menschen

1899-12-01

Neue Auffassungen über einen Grundbegriff der Atemmechanik

1929-01-01

K. Neergaard

Die komplexometrische Titration

1955-01-01

C. Jegge

Drei Vortrage uber Diffusion, Brownsche Bewegung und Koagulation von Kolloidteilchen

1916-01-01

Marian Smoluchowski

Elemente der Psychophysik

1889-08-01

J. J. , Gustav Theodor Fechner

Die Hochmolekularen Organischen Verbindungen

1932-01-01

H. Staudinger

Über humorale übertragbarkeit der Herznervenwirkung

1921-12-01

O. Loewi

Über die Sauerstoffversorgung des Gehirns und den Mechanismus von Mangelwirkungen

1950-12-01

Erich Opitz , Max Schneider

Über das Überschreiten von Potentialschwellen bei chemischen Reaktionen

1932-09-01

E. P. Wigner

METHODEN DER ORGANISCHEN CHEMIE

1966-01-01

METHODEN DER ORGANISCHEN CHEMIE

1962-01-01

Gesammelte Abhandlungen zur funktionellen Anatomie des Bewegungsapparates

1965-01-01

Friedrich Pauwels

Lehrbuch der Muskel- und Gelenkmechanik

1913-01-01

H. Straßer

Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen

1925-01-01

C. v. Economo , Georg N. Koskinas

Wuchsstoff und Wachstum

1927-01-01

F. W. Went

Die wichtigsten Ergebnisse der vorliegenden Arbeit konnen folgenderweise zusammengefasst werden. Die stetige Bildung (12) eines physikalisch zu handhabenden wachstumsfordernden Stoffes (Wuchsstoff) in der aussersten Spitze einer Avena-Koleoptile wird bewiesen (1), … Die wichtigsten Ergebnisse der vorliegenden Arbeit konnen folgenderweise zusammengefasst werden. Die stetige Bildung (12) eines physikalisch zu handhabenden wachstumsfordernden Stoffes (Wuchsstoff) in der aussersten Spitze einer Avena-Koleoptile wird bewiesen (1), (5), (6), (20). Eine Methode zur quantitativen Analyse dieses Stoffes ist ausgearbeitet worden (1), (4), (9), (10), (11), (12), (13) und hat es moglich gemacht folgende Eigenschaften desselben zu bestimmen. Innerhalb gewisser Grenzen beschrankt der Wuchsstoff das Wachstum vollig (9) und ist das Wachstum der Wuchsstoffmenge proportional (9), (13); ohne Wuchsstoff kein Wachstum (38), (42). *) Der Wuchsstoff ist licht- (36) und hitzebestandig (37), hat ein Molekulargewicht zwischen 350 und 400 (29), und wird beim Wachstum aufgebraucht (32), (40). Wahrschein- lieh ist er nicht spezifisch (48) und bewirkt nur eine erhohte Dehnbarkeit der Zellwand (49). In der Koleoptile ist der Wuchsstoffstrom polar (31), (33), die Konzentration des Stoffes nimmt basalwarts ab (41). Ein anderer Faktor, Zellstreckungsmaterial genannt, beschrankt das vom Wuchsstoff hervorgerufene Wachstum (14), (15), (43), (45); in der Koleoptile nimmt seine Konzentration basal warts zu (46). Wuchsstoff und Zellstreckungsmaterial sind die einzig nachweisbaren inneren „limiting factors” des Wachstums (14), (15), (39), mittels diesen beiden ist das normale Wachstum einer Koleoptile vollig erklarlich (47), (47a). Die nicht mehr wachsenden basalen Koleoptilzonen haben ihr Wachstum nur durch Wuchsstoffmangel eingestellt (42). Das Wachstum des Mesokotyls wird ebenfalls vom Wuchsstoff bedingt (44). Eine geringe Lichtmenge (1000 M.K.S.) ruft sofort eine kurz anhaltende Verringerung der aus der Spitze hinausdiffundierenden Wuchsstoffmenge hervor (52), welche die Lichtwachstumsreaktion veranlasst (53). Einseitig einfallendes Licht lenkt den sonst allseitig aus der Spitze kommenden Wuchsstoffstrom derweise ab, dass die Lichtflanke sehr wenig (58) und die Schattenflanke einen Uberschuss des Wuchsstoffes empfangt (56), (59), (60), welche Wuchsstoffdifferenz vollstandig genugt um die phototropischen Krummungen zu erklaren; es gibt also keine phototropischen Reizstoffe (51), (61). Als Folge der erhaltenen Resultate muss die Theorie von Blaauw fur die Erklarung der phototropischen Krummung nach Spitzenreizung abgelehnt werden (54); der Lichtabfall ist fur die Entstehung der letzteren bestimmend. Am Schluss dieser Arbeit, die ganz im Botanischen Institut der Utrechter Universitat bearbeitet wurde, muss ich meinem Lehrer und Vater Herrn Prof. Dr. F. A. F. C. Went meinen besonderen Dank aussprechen fur so manche Anweisung und namentlich fur seine ausserst scharfe Kritik, mittels welcher er meine Arbeit stetig gefordert hat. Herrn Prof. Dr. L. G. M Baas-Becking danke ich fur vielerlei Anregung, und schliesslich bin ich Herrn Assistenten H. E. Dolk sehr verplichtet fur alle Hilfe und die Uberlassung einiger sehr wichtigen Versuchsresultate.

Nasogastrale Sonde legen – Schritt für Schritt

2025-06-25

Dominik Mastragostino | retten!

Akupressur in der Pflege: Brückenschlag zwischen Tradition und Evidenz

2025-06-23

Qiumei Jiang‐Siebert | Deutsche Zeitschrift für Akupunktur

Auswirkung osteopathischer Behandlungen auf asthmatische Erkrankungen

2025-06-23

| DO - Deutsche Zeitschrift für Osteopathie

Funktionsmedizin und Versorgungsmanagement

2025-06-18

Volker Liefring , Lothar Beyer , Egbert Seidel +1 more | Manuelle Medizin

Resonanz bei Tonhölzern

2025-06-15

Richard Wegmann | Vandenhoeck & Ruprecht eBooks

Das Koordinatensystem des Menschen — die Polarisationsebenen — der Polarisationsfilter

2025-06-01

Franz Jost , Sandra Waldis , Vincenzo Nirchio | Akupunktur & Aurikulomedizin

Heimdialyse 2025

2025-06-01

Benno Kitsche | Nephrologie aktuell

Was tun bei Sonnenallergie?

2025-06-01

Nicola Zink | HautinForm

Die Wasserkraft - das ungeliebte Kind

2025-06-01

| WASSERWIRTSCHAFT

Senotherapeutika im Trend

2025-06-01

Kathrin von Kieseritzky | Deleted Journal

Robinson-Drainage: kleines Hilfsmittel – große Wirkung im OP-Alltag

2025-06-01

Sandra Gädtke | Im OP

Im dritten Teil unserer Serie zum Thema Drainagen lernen Sie die Funktionsweise, Anwendungsgebiete, Indikationen, Kontraindikationen sowie Vor- und Nachteile der Robinson-Drainage kennen. Im dritten Teil unserer Serie zum Thema Drainagen lernen Sie die Funktionsweise, Anwendungsgebiete, Indikationen, Kontraindikationen sowie Vor- und Nachteile der Robinson-Drainage kennen.

Riskanter Hype um „Anterior vertebral body tethering“

2025-06-01

Elke Oberhofer | Orthopädie & Rheuma

BrainTwister

2025-06-01

| The New Scientist

Wenn die Funken fliegen

2025-05-30

Stefan Albus | Nachrichten aus der Chemie

Abstract Köln, Messe, Halle 10.1: Feuerlöscher, Brandmelder, Flammschutzmittel. Wir erkunden die Brandschutztage des Unternehmens VdS Schadensverhütung – eine chemische Spielwiese. Heiß her geht es nicht nur bei der Brandbekämpfung, sondern … Abstract Köln, Messe, Halle 10.1: Feuerlöscher, Brandmelder, Flammschutzmittel. Wir erkunden die Brandschutztage des Unternehmens VdS Schadensverhütung – eine chemische Spielwiese. Heiß her geht es nicht nur bei der Brandbekämpfung, sondern auch im Regulierungsfeuer.

Nrf2/AMPK axis is required for redox-mediated phase resetting of musculoskeletal clocks upon acute mechanical loading

2025-05-30

Ufuk Ersoy , Cal Sibel , Phaedra Winstanley-Zarach +3 more | Free Radical Biology and Medicine

Manejo atual da asma na infância: diagnóstico, classificação e abordagens terapêuticas baseadas em diretrizes

2025-05-29

Giselle Moraes Candido , Alberto Costa , Félix Guerrero-Ramos +2 more | Brazilian Journal of Health Review

O manejo da asma na infância requer uma visão integrada que articule epidemiologia, diagnóstico, tratamento e acompanhamento clínico. Inicialmente, destaca-se a alta prevalência e o impacto socioeconômico da asma em … O manejo da asma na infância requer uma visão integrada que articule epidemiologia, diagnóstico, tratamento e acompanhamento clínico. Inicialmente, destaca-se a alta prevalência e o impacto socioeconômico da asma em crianças, justificando a necessidade de práticas baseadas em evidências. A compreensão dos fatores de risco — como predisposição genética, exposições ambientais (alérgenos, poluição, tabagismo passivo) e condições socioeconômicas — orienta ações preventivas desde os primeiros anos. No diagnóstico clínico, a avaliação cuidadosa dos sintomas (dispneia, sibilos, despertares noturnos) e a exclusão de outras causas respiratórias, associadas a espirometria em crianças maiores, permitem classificar a gravidade (intermitente, persistente leve, moderada ou grave). Essa categorização é vital para guiar o tratamento escalonado, conforme diretrizes internacionais (GINA, SBPT). As estratégias terapêuticas combinam medicamentos de alívio (β2-agonistas) e controle (corticosteroides inalatórios, antileucotrienos), estruturados em passos de intensificação ou redução de dose, sempre acompanhados por plano de ação escrito. A educação de cuidadores e a instrução sobre uso de espaçadores fortalecem a adesão. Por fim, o acompanhamento clínico contínuo — monitorando frequência de sintomas, uso de resgate, limitação de atividades e função pulmonar — permite ajustes terapêuticos pontuais (step-up/step-down) e reforço educacional. Consultas periódicas transformam-se em momentos de avaliação e suporte, garantindo controle sustentado da doença e melhor qualidade de vida para a criança asmática.

PATIENTS WITH ALLERGIES – PREOPERATIVE PREPARATION AND PREMEDICATION

2025-05-28

Гергана Иванова , Margarita Atanasova | Journal of IMAB - Annual Proceeding (Scientific Papers)

Purpose: The study investigates the need and effectiveness of preoperative prick test corticosteroids as antiallergic premedication for patients with a history of allergic reactions undergoing surgery under general anesthesia, focusing … Purpose: The study investigates the need and effectiveness of preoperative prick test corticosteroids as antiallergic premedication for patients with a history of allergic reactions undergoing surgery under general anesthesia, focusing on hypersensitivity reactions (HSRs). Material and Methods: A prospective clinical-epidemiological study was conducted with 60 patients, divided into groups receiving corticosteroid premedication (30 patients) and no premedication (30 patients). Patients had histories of allergies, and hypersensitivity was monitored intraoperatively and postoperatively. Data were analyzed using various statistical methods to assess the impact of corticosteroid use and prick tests. Results: The study revealed no significant reduction in the incidence of mild or moderate-to-severe HSRs with corticosteroid premedication. Allergic reactions, including rash and bronchospasm, were observed in three patients despite receiving corticosteroids. Additionally, the absence of corticosteroid or H1/H2 blocker premedication did not increase the incidence of HSRs in other patients. Statistical analysis demonstrated a lack of correlation between premedication and the prevention of allergic reactions. The study proved that prick tests are not a reliable method to identify possible triggers of HSRs Conclusion: Corticosteroid premedication does not effectively prevent perioperative HSRs in patients with allergic conditions. The study suggests that routine use of corticosteroids for this purpose should be reconsidered. A detailed allergy history is crucial for identifying at-risk patients, rather than prick tests and national protocols for managing perioperative HSRs reactions should be developed.

Hypertonie-Schulung in der Notaufnahme

2025-05-28

27. Symposium des Deutschen Osteopathie Kollegs

2025-05-28

Valerie Karl | Osteopathische Medizin

ROD: Register der Traditionellen Osteopathen in Deutschland Gmbh

2025-05-28

Osteopathische Behandlungeines Reizdarmsyndroms

2025-05-28

Frank Scheuchl , Gunnar Spohr | Osteopathische Medizin

BAO: Bundes Arbeitsgemeinschaft Osteopathie e.V.

2025-05-28

DVOM: Deutscher Verband für Osteopathische Medizin e.v.

2025-05-28

Deutsch-Amerikanische Akademie für Osteopathie (DAAO) e.v.

2025-05-28

Aufruf zur Unterstützung einer Interviewstudie zu Erwartungen und Erfahrungen von Osteopathie-Patient*innen

2025-05-28

Helge Franke , Gabi Prediger , Dirk Luthin +2 more | Osteopathische Medizin

Halo-Effekt

2025-05-28

Für die präzise Ventilsteuerung

2025-05-27

Praktische Erfahrungen bei der Anwendung des Feuchtigkeitszustands‐Werts (MCV) im Erdbau

2025-05-27

Christoph Henzinger , Clemens Krösbacher , Melanie Gantner

Abstrakt Die Bestimmung des MCV (Moisture Condition Value, zu Deutsch „Feuchtigkeitszustands‐Wert“) erlaubt die Beurteilung der Eignung eines bindigen Erdbaustoffes für die Verdichtung. Es kann damit innerhalb sehr kurzer Zeit festgestellt … Abstrakt Die Bestimmung des MCV (Moisture Condition Value, zu Deutsch „Feuchtigkeitszustands‐Wert“) erlaubt die Beurteilung der Eignung eines bindigen Erdbaustoffes für die Verdichtung. Es kann damit innerhalb sehr kurzer Zeit festgestellt werden, ob der Wassergehalt des Erdbaustoffes im Bereich des optimalen Wassergehalts nach Proctor liegt bzw. wie viel Wasser oder Bindemittel zugegeben werden muss, damit ein solcher Wassergehalt erreicht wird. Im Rahmen der Erstellung eines Probedamms für das Hochwasserschutzprojekt Alpenrhein km 65–91 wurde die praktische Anwendung des Versuches dokumentiert. Es wurden dabei das Verdichtungsverfahren vorgegeben und die Eignung des eingebauten Materials für die Verdichtung jeweils direkt vor der Verdichtung mit dem MCV‐Wert überprüft bzw. die einzumischende Bindemittelmenge anhand des MCV‐Werts festgelegt. Am fertigen Produkt wurden Dichtebestimmungen für die Verdichtungskontrolle anhand der direkten Prüfmerkmale durchgeführt. Im vorliegenden Beitrag werden die Erfahrungen vorgestellt und insbesondere in Bezug auf die Prüfmerkmale Verdichtungsgrad ( D Pr ) und Luftporenanteil ( n a ) ausgewertet.

Konzernbonus

2025-05-24

Mitteilungen der Deutschen Schmerzgesellschaft e.V.

2025-05-22

Autologes, passager „konditioniertes“ Venenmaterial – eine alternative Option für den arteriellen Gefäßersatz

2025-05-21

M. Nasif , U. Barth , Frank Meyer +1 more

Die unverletzte Extremität als Referenz für den Extremitätensymmetrieindex

2025-05-21

Stablecoins and their regulation: a Hayekian approach

2025-05-21

Fırat Cengiz

Abstract This article critically investigates stablecoins and the emerging global regulatory landscape targeting them. Frederich Hayek’s currency competition model is utilized as the main analytical framework for this investigation. The … Abstract This article critically investigates stablecoins and the emerging global regulatory landscape targeting them. Frederich Hayek’s currency competition model is utilized as the main analytical framework for this investigation. The article aims to answer two fundamental questions: Are stablecoins Hayekian currencies? If so, how will the emerging regulations affect the currency competition? The article finds that stablecoins satisfy some key conditions of the Hayekian model, such as stability, transparency, and a robust technological framework. Nevertheless, unlike Hayekian currencies, stablecoins are not anti-inflationary and benefit from somewhat limited competitive discipline. The article also finds that some aspects of the emerging regulations will further limit the operation of stablecoins as Hayekian currencies. This is particularly the case for stricter prudential standards imposed on stablecoins compared with other mediums of exchange and the ban on interest. However, if stablecoins comply with the regulatory standards without compromising innovation, they might emerge as superior-quality Hayekian currencies and impose competitive pressure on other private and public sources of money to follow equally robust prudential standards.

Gesicherte Standards zur Behandlung akuter peri- und posttraumatischer Schmerzen

2025-05-19

H. Wenk , M. Gawenda , T. Bürger

Risks of Vaginal and Sexually Transmitted Infections With Copper Intrauterine Devices Compared to Levonorgestrel Intrauterine Devices [ID 1225]

2025-05-15

Celeste Traub , Samuel H. Wood , Kathleen Karam +2 more

INTRODUCTION: Copper (Cu-IUDs) and levonorgestrel intrauterine devices (LNG-IUDs) have differing effects on the vaginal mucosa. Copper IUDs have been reported to induce a local inflammatory response and to increase bacterial … INTRODUCTION: Copper (Cu-IUDs) and levonorgestrel intrauterine devices (LNG-IUDs) have differing effects on the vaginal mucosa. Copper IUDs have been reported to induce a local inflammatory response and to increase bacterial vaginosis risk. Levonorgestrel-IUD use suppresses endometrial growth and thickens cervical mucus. This study explores vaginal health outcomes and infection risks associated with Cu-IUDs compared to LNG-IUDs via retrospective chart review. METHODS: TriNetX platform was accessed to analyze risk outcomes of deidentified data. Using Healthcare Common Procedure Coding System and RxNorm codes, study cohorts (n=73,123) were created to include women with a Cu-IUD versus women with a LNG-IUD. Cohorts were matched for age, race, and ethnicity. Statistical analysis within 3 years of IUD placement used risk ratios (RRs), with 95% CI determining significance. RESULTS: Copper IUDs showed increased risk of chronic vulvitis (RR 1.46; CI, 1.37–1.56), acute vulvitis (RR 1.41; CI, 1.32–1.51), chlamydia (RR 1.41; CI, 1.29–1.53), chronic vaginitis (RR 1.40; CI, 1.32–1.50), syphilis (RR 1.40; CI, 1.23–1.60), gonorrhea (RR 1.37; CI, 1.25–1.51), human immunodeficiency virus (HIV) (RR 1.27; CI, 1.13–1.42), and acute vaginitis (RR 1.12; CI, 1.08–1.17). Copper IUDs showed a decreased risk for pelvic inflammatory disease (RR 0.85; CI, 0.77–0.98). P values for all risk differences are less than .005. There were no significant differences in risk for herpes simplex virus 2, anogenital warts, candidiasis, or trichomoniasis. CONCLUSIONS/IMPLICATIONS: Women using Cu-IUDs had increased risks for vulvitis, chlamydia, vaginitis, syphilis, gonorrhea, and HIV and decreased risk of pelvic inflammatory disease compared to LNG-IUDs. Further investigation of copper and levonorgestrel effects on the female reproductive microbiome compared to women who do not use IUDs is warranted.

Constipation as a Presentation of Duchenne Muscular Dystrophy

2025-05-14

Dhruv Gandhi , Ira Shah