Chemistry › Spectroscopy

Molecular Sensors and Ion Detection

Works Count: 59881

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Description

This cluster of papers focuses on the development and application of fluorescent chemosensors for the detection of various ions, including anions and metal ions, as well as their use in bioimaging. The papers cover topics such as anion recognition, reactive oxygen species detection, molecular sensors, and supramolecular chemistry. Additionally, there is a specific emphasis on the role of fluorescent chemosensors in studying neurodegenerative diseases.

Keywords

Fluorescent Chemosensors; Ion Detection; Bioimaging; Anion Recognition; Metal Ions; Fluorescent Probes; Reactive Oxygen Species; Molecular Sensors; Supramolecular Chemistry; Neurodegenerative Diseases

The Cation−π Interaction

1997-08-01

C. Jennifer , Dennis A. Dougherty

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Cation−π InteractionJennifer C. Ma and Dennis A. DoughertyView Author Information Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute … ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Cation−π InteractionJennifer C. Ma and Dennis A. DoughertyView Author Information Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125 Cite this: Chem. Rev. 1997, 97, 5, 1303–1324Publication Date (Web):August 5, 1997Publication History Received20 December 1996Revised17 March 1997Published online5 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/cr9603744https://doi.org/10.1021/cr9603744research-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views24174Altmetric-Citations3112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Ions,Monomers,Peptides and proteins,Receptors Get e-Alerts

A23187: A Divalent Cation Ionophore

1972-11-01

Peter Reed , Henry A. Lardy

A23187 is a carboxylic acid antibiotic which simultaneously uncouples oxidative phosphorylation and inhibits ATPase of rat liver mitochondria incubated in a magnesium-free medium. The antibiotic acts as a freely mobile … A23187 is a carboxylic acid antibiotic which simultaneously uncouples oxidative phosphorylation and inhibits ATPase of rat liver mitochondria incubated in a magnesium-free medium. The antibiotic acts as a freely mobile carrier to transport calcium and magnesium, but not potassium, from an aqueous medium buffered at pH 7.4 into a bulk organic phase. A23187 causes a progressive release of endogenous magnesium and inorganic phosphate from mitochondria incubated with substrate, but little change in calcium or potassium content. If EDTA is added, A23187 severely depletes intramitochondrial calcium and magnesium in Release of State 4 succinate oxidation by A23187 is inhibited by lanthanum chloride, ruthenium red, ((ethylene bis)oxyethylene nitrilo)tetraacetic acid (EGTA), EDTA, MgCl2, and ATP. Inhibition by EGTA (or EDTA) of A23187′s uncoupling is reversed readily by calcium but not magnesium. In the presence of A23187 plus EGTA, mitochondria retain only 2 to 3 nmoles of Mg2+ per mg of protein but remain coupled and phosphorylate ADP at 80 to 85% of control rates with β-hydroxybutyrate or succinate as substrate. Under these conditions, coupled phosphorylation supported by glutamate, and ATP hydrolysis are severely depressed, but increasing concentrations of magnesium in the incubating medium prevent these inhibitions. It is proposed that a cyclic, energy-dissipating flux of mitochondrial calcium accounts for uncoupling by A23187, whereas inhibition of ATPase and glutamate oxidation and increased potassium permeability of mitochondria result from antibiotic-mediated magnesium efflux.

Optical chemosensors and reagents to detect explosives

2011-09-23

Yolanda Salinas , Ramón Martínez‐Máñez , M. Dolores Marcos +4 more

This critical review is focused on examples reported from 1947 to 2010 related to the design of chromo-fluorogenic chemosensors and reagents for explosives (141 references). This critical review is focused on examples reported from 1947 to 2010 related to the design of chromo-fluorogenic chemosensors and reagents for explosives (141 references).

A colorimetric method for determining low concentrations of mercaptans

1958-04-01

George L. Ellman

Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging

2012-10-23

Lin Yuan , Weiying Lin , Kaibo Zheng +2 more

The long wavelength (far-red to NIR) analyte-responsive fluorescent probes are advantageous for in vivo bioimaging because of minimum photo-damage to biological samples, deep tissue penetration, and minimum interference from background … The long wavelength (far-red to NIR) analyte-responsive fluorescent probes are advantageous for in vivo bioimaging because of minimum photo-damage to biological samples, deep tissue penetration, and minimum interference from background auto-fluorescence by biomolecules in the living systems. Thus, great interest in the development of new long wavelength analyte-responsive fluorescent probes has emerged in recent years. This review highlights the advances in the development of far-red to NIR fluorescent probes since 2000, and the probes are classified according to their organic dye platforms into various categories, including cyanines, rhodamine analogues, BODIPYs, squaraines, and other types (240 references).

New sensing mechanisms for design of fluorescent chemosensors emerging in recent years

2011-01-01

Jiasheng Wu , Weimin Liu , Jiechao Ge +2 more

During the past decade, fluorescent chemosensors have become an important research field of supramolecular chemistry and have attracted great attention because of their simplicity, high selectivity and sensitivity in fluorescent … During the past decade, fluorescent chemosensors have become an important research field of supramolecular chemistry and have attracted great attention because of their simplicity, high selectivity and sensitivity in fluorescent assays. In the design of new fluorescent chemosensors, exploration of new sensing mechanisms between recognition and signal reporting units is of continuing interest. Based on different photophysical processes, conventional sensing mechanisms including photo-induced electron transfer (PET), intramolecular charge transfer (ICT), metal-ligand charge transfer (MLCT), twisted intramolecular charge transfer (TICT), electronic energy transfer (EET), fluorescence resonance energy transfer (FRET), and excimer/exciplex formation have been investigated and reviewed extensively in the literature. This tutorial review will mainly focus on new fluorescent sensing mechanisms that have emerged in the past five years, such as aggregation-induced emission (AIE) and C=N isomerization, which can be ascribed to fluorescence changes via conformational restriction. In addition, excited-state intramolecular proton transfer (ESIPT) has not been well reviewed yet, although a number of chemosensors based on the ESIPT mechanism have been reported. Thus, ESIPT-based chemosensors have been also summarized in this review.

Interactions of histidine and other imidazole derivatives with transition metal ions in chemical and biological systems

1974-08-01

Richard J. Sundberg , R. Bruce Martin

ADVERTISEMENT RETURN TO ISSUEPREVArticleInteractions of histidine and other imidazole derivatives with transition metal ions in chemical and biological systemsRichard J. Sundberg and R. Bruce MartinCite this: Chem. Rev. 1974, 74, … ADVERTISEMENT RETURN TO ISSUEPREVArticleInteractions of histidine and other imidazole derivatives with transition metal ions in chemical and biological systemsRichard J. Sundberg and R. Bruce MartinCite this: Chem. Rev. 1974, 74, 4, 471–517Publication Date (Print):August 1, 1974Publication History Published online1 May 2002Published inissue 1 August 1974https://pubs.acs.org/doi/10.1021/cr60290a003https://doi.org/10.1021/cr60290a003research-articleACS PublicationsRequest reuse permissionsArticle Views7788Altmetric-Citations977LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Helicates as Versatile Supramolecular Complexes

1997-10-01

Claude Piguet , Gérald Bernardinelli , Gérard Hopfgartner

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHelicates as Versatile Supramolecular ComplexesClaude Piguet, Gérald Bernardinelli, and Gérard HopfgartnerView Author Information Department of Inorganic, Analytical and Applied Chemistry and the Laboratory of X-ray Crystallography, University … ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHelicates as Versatile Supramolecular ComplexesClaude Piguet, Gérald Bernardinelli, and Gérard HopfgartnerView Author Information Department of Inorganic, Analytical and Applied Chemistry and the Laboratory of X-ray Crystallography, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland, and Pharma Division, F. Hoffmann-La Roche Ltd CH-4070 Basle, Switzerland Cite this: Chem. Rev. 1997, 97, 6, 2005–2062Publication Date (Web):October 1, 1997Publication History Received10 December 1996Revised29 April 1997Published online1 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/cr960053shttps://doi.org/10.1021/cr960053sresearch-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views7256Altmetric-Citations1527LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Crystal structure,Ions,Ligands,Metals,Self organization Get e-Alerts

Artificial Organic Host Molecules for Anions

1997-08-01

Franz P. Schmidtchen , Michael Berger

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTArtificial Organic Host Molecules for AnionsFranz P. Schmidtchen and Michael BergerView Author Information Institut für Organische Chemie und Biochemie, Technische Universität München, D-85747 Garching, Germany Cite this: … ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTArtificial Organic Host Molecules for AnionsFranz P. Schmidtchen and Michael BergerView Author Information Institut für Organische Chemie und Biochemie, Technische Universität München, D-85747 Garching, Germany Cite this: Chem. Rev. 1997, 97, 5, 1609–1646Publication Date (Web):August 5, 1997Publication History Received23 January 1997Revised23 May 1997Published online5 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/cr9603845https://doi.org/10.1021/cr9603845research-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views7276Altmetric-Citations1608LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Cations,Complexation,Receptors,Selectivity Get e-Alerts

Fluorescent Sensors for Measuring Metal Ions in Living Systems

2014-03-03

Kyle P. Carter , Alexandra M. Young , Amy E. Palmer

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFluorescent Sensors for Measuring Metal Ions in Living SystemsKyle P. Carter, Alexandra M. Young, and Amy E. Palmer*View Author InformationDepartment of Chemistry and Biochemistry, BioFrontiers Institute, University … ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFluorescent Sensors for Measuring Metal Ions in Living SystemsKyle P. Carter, Alexandra M. Young, and Amy E. Palmer*View Author InformationDepartment of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado, UCB 596, 3415 Colorado AvenueBoulder, Colorado 80303, United States*E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 8, 4564–4601Publication Date (Web):March 3, 2014Publication History Received4 October 2013Published online3 March 2014Published inissue 23 April 2014https://doi.org/10.1021/cr400546eCopyright © 2014 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views46107Altmetric-Citations1566LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (8 MB) Get e-AlertsSUBJECTS:Sensors,Metals,Fluorescence,Probes,Ions Get e-Alerts

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Fluorogenic and Chromogenic Chemosensors and Reagents for Anions

2003-10-28

Ramón Martínez‐Máñez , Félix Sancenón

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorogenic and Chromogenic Chemosensors and Reagents for AnionsRamón Martínez-Máñez and Félix SancenónView Author Information GDDS, Departamento de Química, Universidad Politécnica de Valencia, Camino de Vera s/n, 46071-Valencia, … ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorogenic and Chromogenic Chemosensors and Reagents for AnionsRamón Martínez-Máñez and Félix SancenónView Author Information GDDS, Departamento de Química, Universidad Politécnica de Valencia, Camino de Vera s/n, 46071-Valencia, Spain Cite this: Chem. Rev. 2003, 103, 11, 4419–4476Publication Date (Web):October 28, 2003Publication History Received16 May 2003Published online28 October 2003Published inissue 1 November 2003https://pubs.acs.org/doi/10.1021/cr010421ehttps://doi.org/10.1021/cr010421eresearch-articleACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views15917Altmetric-Citations2865LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Color,Fluorescence,Quenching,Receptors Get e-Alerts

Design principles of fluorescent molecular sensors for cation recognition

2000-08-01

Bernard Valeur

Tools and Tactics for the Optical Detection of Mercuric Ion

2008-07-25

Elizabeth M. Nolan , Stephen J. Lippard

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTTools and Tactics for the Optical Detection of Mercuric IonElizabeth M. Nolan and Stephen J. Lippard*View Author Information Department of Chemistry, Massachusetts Institute of Technology, Cambridge Massachusetts … ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTTools and Tactics for the Optical Detection of Mercuric IonElizabeth M. Nolan and Stephen J. Lippard*View Author Information Department of Chemistry, Massachusetts Institute of Technology, Cambridge Massachusetts 02139* To whom correspondence should be addressed. E-mail: [email protected]Cite this: Chem. Rev. 2008, 108, 9, 3443–3480Publication Date (Web):July 25, 2008Publication History Received9 November 2007Published online25 July 2008Published inissue 10 September 2008https://pubs.acs.org/doi/10.1021/cr068000qhttps://doi.org/10.1021/cr068000qreview-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views15064Altmetric-Citations2169LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Fluorescence,Fluorescence detection,Ions,Probes,Sensors Get e-Alerts

Fluorescent indicators based on BODIPY

2011-07-28

Noël Boens , Volker Leen , Wim Dehaen

This critical review covers the advances made using the 4-bora-3a,4a-diaza-s-indacene (BODIPY) scaffold as a fluorophore in the design, synthesis and application of fluorescent indicators for pH, metal ions, anions, biomolecules, … This critical review covers the advances made using the 4-bora-3a,4a-diaza-s-indacene (BODIPY) scaffold as a fluorophore in the design, synthesis and application of fluorescent indicators for pH, metal ions, anions, biomolecules, reactive oxygen species, reactive nitrogen species, redox potential, chemical reactions and various physical phenomena. The sections of the review describing the criteria for rational design of fluorescent indicators and the mathematical expressions for analyzing spectrophotometric and fluorometric titrations are applicable to all fluorescent probes (206 references).

A detailed examination of boronic acid–diol complexation

2002-06-01

Greg Springsteen , Binghe Wang

Highly Selective Oligonucleotide‐Based Sensor for Mercury(<scp>II</scp>) in Aqueous Solutions

2004-08-13

Akira Ono , Humika Togashi

Mercury gauge: An oligodeoxyribonucleotide(ODN)-based sensor, which carries energy-donor and -acceptor moieties (fluorescein, F, and dabcyl, D, respectively), selectively detects HgII ions in aqueous solution. Upon binding HgII ions, the ODN … Mercury gauge: An oligodeoxyribonucleotide(ODN)-based sensor, which carries energy-donor and -acceptor moieties (fluorescein, F, and dabcyl, D, respectively), selectively detects HgII ions in aqueous solution. Upon binding HgII ions, the ODN takes on a hairpin structure (see picture); this results in a decrease in the fluorescence emission through enhanced FRET (fluorescence resonance energy transfer) from F to D. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z54172_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Fluorescent and colorimetric sensors for detection of lead, cadmium, and mercury ions

2011-12-19

Ha Na Kim , Wen Xiu Ren , Jong Seung Kim +1 more

Exposure to even very low levels of lead, cadmium, and mercury ions is known to cause neurological, reproductive, cardiovascular, and developmental disorders, which are more serious problems for children particularly. … Exposure to even very low levels of lead, cadmium, and mercury ions is known to cause neurological, reproductive, cardiovascular, and developmental disorders, which are more serious problems for children particularly. Accordingly, great efforts have been devoted to the development of fluorescent and colorimetric sensors, which can selectively detect lead, cadmium, and mercury ions. In this critical review, the fluorescent and colorimetric sensors are classified according to their receptors into several categories, including small molecule based sensors, calixarene based chemosensors, BODIPY based chemosensors, polymer based chemosensors, DNA functionalized sensing systems, protein based sensing systems and nanoparticle based sensing systems (197 references).

Reaction-based small-molecule fluorescent probes for chemoselective bioimaging

2012-11-23

Jefferson Chan , Sheel C. Dodani , Christopher J. Chang

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Interactions with Aromatic Rings in Chemical and Biological Recognition

2003-03-13

Emmanuel A. Meyer , Ronald K. Castellano , François Diederich

Abstract Intermolecular interactions involving aromatic rings are key processes in both chemical and biological recognition. Their understanding is essential for rational drug design and lead optimization in medicinal chemistry. Different … Abstract Intermolecular interactions involving aromatic rings are key processes in both chemical and biological recognition. Their understanding is essential for rational drug design and lead optimization in medicinal chemistry. Different approaches—biological studies, molecular recognition studies with artificial receptors, crystallographic database mining, gas‐phase studies, and theoretical calculations—are pursued to generate a profound understanding of the structural and energetic parameters of individual recognition modes involving aromatic rings. This review attempts to combine and summarize the knowledge gained from these investigations. The review focuses mainly on examples with biological relevance since one of its aims it to enhance the knowledge of molecular recognition forces that is essential for drug development.

Colorimetric and fluorescent anion sensors: an overview of recent developments in the use of 1,8-naphthalimide-based chemosensors

2010-01-01

Rebecca M. Duke , Emma B. Veale , Frederick M. Pfeffer +2 more

This critical review focuses on the development of anion sensors, being either fluorescent and/or colorimetric, based on the use of the 1,8-naphthalimide structure; a highly versatile building unit that absorbs … This critical review focuses on the development of anion sensors, being either fluorescent and/or colorimetric, based on the use of the 1,8-naphthalimide structure; a highly versatile building unit that absorbs and emits at long wavelengths. The review commences with a short description of the most commonly used design principles employed in chemosensors, followed by a discussion on the photophysical properties of the 4-amino-1,8-naphthalimide structure which has been most commonly employed in both cation and anion sensing to date. This is followed by a review of the current state of the art in naphthalimide-based anion sensing, where systems using ureas, thioureas and amides as hydrogen-bonding receptors, as well as charged receptors have been used for anion sensing in both organic and aqueous solutions, or within various polymeric networks, such as hydrogels. The review concludes with some current and future perspectives including the use of the naphthalimides for sensing small biomolecules, such as amino acids, as well as probes for incorporation and binding to proteins; and for the recognition/sensing of polyanions such as DNA, and their potential use as novel therapeutic and diagnostic agents (95 references).

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Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules

2014-10-06

Min Hee Lee , Jong Seung Kim , Jonathan L. Sessler

Quantitative determination of specific analytes is essential for a variety of applications ranging from life sciences to environmental monitoring. Quantitative determination of specific analytes is essential for a variety of applications ranging from life sciences to environmental monitoring.

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New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980-05-01

Roger Y. Tsien

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structuresRoger Y. TsienCite this: Biochemistry 1980, 19, 11, 2396–2404Publication … ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structuresRoger Y. TsienCite this: Biochemistry 1980, 19, 11, 2396–2404Publication Date (Print):May 27, 1980Publication History Published online1 May 2002Published inissue 27 May 1980https://doi.org/10.1021/bi00552a018RIGHTS & PERMISSIONSArticle Views5453Altmetric-Citations1633LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts

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A new trend in rhodamine-based chemosensors: application of spirolactam ring-opening to sensing ions

2008-01-01

Ha Na Kim , Min Hee Lee , Hyun Jung Kim +2 more

This tutorial review focuses on the recent development of rhodamine derivatives, in which the spirolactam (non-fluorescent) to ring-opened amide (fluorescent) process was utilized. This tutorial review focuses on the recent development of rhodamine derivatives, in which the spirolactam (non-fluorescent) to ring-opened amide (fluorescent) process was utilized.

A New Substituent Constant, π, Derived from Partition Coefficients

1964-12-01

Toshio Fujita , Junkichi Iwasa , Corwin Hansch

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Substituent Constant, π, Derived from Partition CoefficientsToshio. Fujita, Junkichi. Iwasa, and Corwin. HanschCite this: J. Am. Chem. Soc. 1964, 86, 23, 5175–5180Publication Date (Print):December 1, … ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Substituent Constant, π, Derived from Partition CoefficientsToshio. Fujita, Junkichi. Iwasa, and Corwin. HanschCite this: J. Am. Chem. Soc. 1964, 86, 23, 5175–5180Publication Date (Print):December 1, 1964Publication History Published online1 May 2002Published inissue 1 December 1964https://pubs.acs.org/doi/10.1021/ja01077a028https://doi.org/10.1021/ja01077a028research-articleACS PublicationsRequest reuse permissionsArticle Views2663Altmetric-Citations1180LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Signaling Recognition Events with Fluorescent Sensors and Switches

1997-08-01

A. Prasanna de Silva , H. Q. Nimal Gunaratne , Thorfinnur Gunnlaugsson +4 more

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSignaling Recognition Events with Fluorescent Sensors and SwitchesA. Prasanna de Silva, H. Q. Nimal Gunaratne, Thorfinnur Gunnlaugsson, Allen J. M. Huxley, Colin P. McCoy, Jude T. Rademacher, … ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSignaling Recognition Events with Fluorescent Sensors and SwitchesA. Prasanna de Silva, H. Q. Nimal Gunaratne, Thorfinnur Gunnlaugsson, Allen J. M. Huxley, Colin P. McCoy, Jude T. Rademacher, and Terence E. RiceView Author Information School of Chemistry, Queen's University, Belfast BT9 5AG, Northern Ireland Cite this: Chem. Rev. 1997, 97, 5, 1515–1566Publication Date (Web):August 5, 1997Publication History Received6 December 1996Revised12 March 1997Published online5 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/cr960386phttps://doi.org/10.1021/cr960386presearch-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views36299Altmetric-Citations6309LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cell signaling,Excited states,Fluorescence,Fluorophores,Receptors Get e-Alerts

Introduction and General Overview of Cyclodextrin Chemistry

1998-06-09

József Szejtli

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntroduction and General Overview of Cyclodextrin ChemistryJózsef SzejtliView Author Information CYCLOLAB, Cyclodextrin Research and Development Laboratory, Budapest, Hungary Cite this: Chem. Rev. 1998, 98, 5, 1743–1754Publication Date … ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntroduction and General Overview of Cyclodextrin ChemistryJózsef SzejtliView Author Information CYCLOLAB, Cyclodextrin Research and Development Laboratory, Budapest, Hungary Cite this: Chem. Rev. 1998, 98, 5, 1743–1754Publication Date (Web):June 9, 1998Publication History Received17 October 1997Revised28 January 1998Published online9 June 1998Published inissue 30 July 1998https://pubs.acs.org/doi/10.1021/cr970022chttps://doi.org/10.1021/cr970022cresearch-articleACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views27203Altmetric-Citations4176LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cadmium sulfide,Macrocyclic compounds,Molecules,Oligosaccharides Get e-Alerts

Luminescent sensors and switches in the early 21st century

2005-06-28

John F. Callan , A. Prasanna de Silva , David C. Magri

Fluoride Ion Complexation and Sensing Using Organoboron Compounds

2010-06-11

Casey R. Wade , A.E.J. Broomsgrove , Simon Aldridge +1 more

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFluoride Ion Complexation and Sensing Using Organoboron CompoundsCasey R. Wade†, Alexander E. J. Broomsgrove‡, Simon Aldridge*‡, and François P. Gabbaï*†View Author Information Chemistry Department, Texas A&M University, … ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFluoride Ion Complexation and Sensing Using Organoboron CompoundsCasey R. Wade†, Alexander E. J. Broomsgrove‡, Simon Aldridge*‡, and François P. Gabbaï*†View Author Information Chemistry Department, Texas A&M University, 3255 TAMU, College Station, Texas 77843-3255, and Inorganic Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QR, United Kingdom* To whom correspondence should be addressed. E-mail: [email protected] (S.A.) and [email protected] (F.P.G.).†Texas A&M University.‡University of Oxford.Cite this: Chem. Rev. 2010, 110, 7, 3958–3984Publication Date (Web):June 11, 2010Publication History Received11 December 2009Published online11 June 2010Published inissue 14 July 2010https://pubs.acs.org/doi/10.1021/cr900401ahttps://doi.org/10.1021/cr900401areview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views11538Altmetric-Citations993LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Boron,Group 13 compounds,Inorganic compounds,Receptors Get e-Alerts

Coumarin-Derived Cu<sup>2+</sup>-Selective Fluorescence Sensor: Synthesis, Mechanisms, and Applications in Living Cells

2009-01-21

Hyo Sung Jung , Pil Seung Kwon , Jeong Won Lee +7 more

A novel coumarin-based fluorogenic probe bearing the 2-picolyl unit (1) was developed as a fluorescent chemosensor with high selectivity and suitable affinity in biological systems toward Cu2+ over other cations … A novel coumarin-based fluorogenic probe bearing the 2-picolyl unit (1) was developed as a fluorescent chemosensor with high selectivity and suitable affinity in biological systems toward Cu2+ over other cations tested. The fluorescence on−off mechanism was studied by femtosecond time-resolved fluorescence (TRF) upconversion technique and ab initio calculations. The receptor can be applied to the monitoring of Cu2+ ion in aqueous solution with a pH span 4−10. To confirm the suitability of 1 for biological applications, we also employed it for the fluorescence detection of the changes of intracellular Cu2+ in cultured cells. The results indicate that 1 should be useful for the fluorescence microscopic imaging and the study on the biological functions of Cu2+.

Anion recognition and sensing in organic and aqueous media using luminescent and colorimetric sensors

2006-08-31

Thorfinnur Gunnlaugsson , Mark Glynn , Gillian M. Tocci +2 more

Fluoro- and Chromogenic Chemodosimeters for Heavy Metal Ion Detection in Solution and Biospecimens

2010-08-20

Dương Tuấn Quang , Jong Seung Kim

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFluoro- and Chromogenic Chemodosimeters for Heavy Metal Ion Detection in Solution and BiospecimensDuong Tuan Quang† and Jong Seung Kim*‡View Author Information Department of Chemistry, Hue University, Hue … ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFluoro- and Chromogenic Chemodosimeters for Heavy Metal Ion Detection in Solution and BiospecimensDuong Tuan Quang† and Jong Seung Kim*‡View Author Information Department of Chemistry, Hue University, Hue 84054, Vietnam, and Department of Chemistry, Korea University, Seoul 136-701, Korea* Corresponding author. E-mail: [email protected]†Hue University.‡Korea University.Cite this: Chem. Rev. 2010, 110, 10, 6280–6301Publication Date (Web):August 20, 2010Publication History Received19 May 2010Published online20 August 2010Published inissue 13 October 2010https://pubs.acs.org/doi/10.1021/cr100154phttps://doi.org/10.1021/cr100154preview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views12745Altmetric-Citations1243LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Fluorescence,Ions,Metals,Probes,Sensors Get e-Alerts

Anion Recognition and Sensing: The State of the Art and Future Perspectives

2001-01-30

Paul D. Beer , Philip A. Gale

Anion recognition chemistry has grown from its beginnings in the late 1960s with positively charged ammonium cryptand receptors for halide binding to, at the end of the millennium, a plethora … Anion recognition chemistry has grown from its beginnings in the late 1960s with positively charged ammonium cryptand receptors for halide binding to, at the end of the millennium, a plethora of charged and neutral, cyclic and acyclic, inorganic and organic supramolecular host systems for the selective complexation, detection, and separation of anionic guest species. Solvation effects and pH values have been shown to play crucial roles in the overall anion recognition process. More recent developments include exciting advances in anion-templated syntheses and directed self-assembly, ion-pair recognition, and the function of anions in supramolecular catalysis.

Synthesis and applications of Rhodamine derivatives as fluorescent probes

2009-01-01

Mariana Beija , Carlos A. M. Afonso , J. M. G. Martinho

Rhodamine dyes are widely used as fluorescent probes owing to their high absorption coefficient and broad fluorescence in the visible region of electromagnetic spectrum, high fluorescence quantum yield and photostability. … Rhodamine dyes are widely used as fluorescent probes owing to their high absorption coefficient and broad fluorescence in the visible region of electromagnetic spectrum, high fluorescence quantum yield and photostability. A great interest in the development of new synthetic procedures for preparation of Rhodamine derivatives has arisen in recent years because for most applications the probe must be covalently linked to another (bio)molecule or surface. In this critical review the strategies for modification of Rhodamine dyes and a discussion on the variety of applications of these new derivatives as fluorescent probes are given (108 references).

Fluorescence probes used for detection of reactive oxygen species

2005-11-05

Ana Gomes , Eduarda Fernandes , José L. F. C. Lima

Determining association constants from titration experiments in supramolecular chemistry

2010-12-02

Pall Thordarson

The most common approach for quantifying interactions in supramolecular chemistry is a titration of the guest to solution of the host, noting the changes in some physical property through NMR, … The most common approach for quantifying interactions in supramolecular chemistry is a titration of the guest to solution of the host, noting the changes in some physical property through NMR, UV-Vis, fluorescence or other techniques. Despite the apparent simplicity of this approach, there are several issues that need to be carefully addressed to ensure that the final results are reliable. This includes the use of non-linear rather than linear regression methods, careful choice of stoichiometric binding model, the choice of method (e.g., NMR vs. UV-Vis) and concentration of host, the application of advanced data analysis methods such as global analysis and finally the estimation of uncertainties and confidence intervals for the results obtained. This tutorial review will give a systematic overview of all these issues-highlighting some of the key messages herein with simulated data analysis examples.

Phosphorescent chemosensors based on heavy-metal complexes

2010-01-01

Qiang Zhao , Fuyou Li , Chunhui Huang

Recently, the use of phosphorescent heavy-metal complexes as chemosensors has attracted increasing interest due to their advantageous photophysical properties. This critical review focuses on the design principles and the recent … Recently, the use of phosphorescent heavy-metal complexes as chemosensors has attracted increasing interest due to their advantageous photophysical properties. This critical review focuses on the design principles and the recent development of phosphorescent chemosensors for metal cations, anions, pH, oxygen, volatile organic compounds and biomolecules based on some heavy-metal complexes (such as Pt(II)-, Ru(II)-, Re(I)-, Ir(III)-, Cu(I)-, Au(I)- and Os(II)-based complexes), in which the variation in phosphorescence signals induced by the interaction between heavy-metal complexes and analytes is utilized (217 references).

Recent progress in the development of near-infrared fluorescent probes for bioimaging applications

2013-09-19

Zhiqian Guo , Sookil Park , Juyoung Yoon +1 more

Near-infrared (NIR) fluorescent dyes have emerged as promising modalities for monitoring the levels of various biologically relevant species in cells and organisms. The use of NIR probes enables deep photon … Near-infrared (NIR) fluorescent dyes have emerged as promising modalities for monitoring the levels of various biologically relevant species in cells and organisms. The use of NIR probes enables deep photon penetration in tissue, minimizes photo-damage to biological samples, and produces low background auto-fluorescence from biomolecules present in living systems. The number of new analyte-responsive NIR fluorescent probes has increased substantially in recent years as a consequence of intense research efforts. In this tutorial review, we highlight recent advances (2010-2013) made in the development and applications of NIR fluorescent probes. The review focuses on NIR fluorescent probes that have been devised to sense various biologically important species, including ROS/RNS, metal ions, anions, enzymes and other related species, as well as intracellular pH changes. The basic principles involved in the design of functional NIR fluorescent probes and suggestions about how to expand applications of NIR imaging agents are also described.

Crown Ethers: Sensors for Ions and Molecular Scaffolds for Materials and Biological Models

2004-03-19

George W. Gokel , W. Matthew Leevy , Michelle E. Weber

ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTCrown Ethers: Sensors for Ions and Molecular Scaffolds for Materials and Biological ModelsGeorge W. Gokel*George W. GokelDepartments of Molecular Biology & Pharmacology and Chemistry, Washington University School … ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTCrown Ethers: Sensors for Ions and Molecular Scaffolds for Materials and Biological ModelsGeorge W. Gokel*George W. GokelDepartments of Molecular Biology & Pharmacology and Chemistry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, Saint Louis, Missouri 63110 To whom correspondence should be addressed. Phone: 314-362-9297. Fax: 314-362-9298. E-mail: [email protected].More by George W. Gokel, W. Matthew LeevyW. Matthew LeevyDepartments of Molecular Biology & Pharmacology and Chemistry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, Saint Louis, Missouri 63110 More by W. Matthew Leevy, and Michelle E. WeberMichelle E. WeberDepartments of Molecular Biology & Pharmacology and Chemistry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, Saint Louis, Missouri 63110 More by Michelle E. WeberCite this: Chem. Rev. 2004, 104, 5, 2723–2750Publication Date (Web):March 19, 2004Publication History Published online19 March 2004Published inissue 1 May 2004https://pubs.acs.org/doi/10.1021/cr020080khttps://doi.org/10.1021/cr020080kresearch-articleACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views18799Altmetric-Citations1282LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cations,Complexation,Ethers,Ions,Macrocyclic compounds Get e-Alerts

Novel Cavity Design Using Calix[<i>n</i>]arene Skeletons: Toward Molecular Recognition and Metal Binding

1997-08-01

Atsushi Ikeda , Seiji Shinkai

ADVERTISEMENT RETURN TO ISSUEPREVArticleNovel Cavity Design Using Calix[n]arene Skeletons: Toward Molecular Recognition and Metal BindingAtsushi Ikeda and Seiji ShinkaiView Author Information Department of Chemical Science & Technology, Faculty of Engineering, … ADVERTISEMENT RETURN TO ISSUEPREVArticleNovel Cavity Design Using Calix[n]arene Skeletons: Toward Molecular Recognition and Metal BindingAtsushi Ikeda and Seiji ShinkaiView Author Information Department of Chemical Science & Technology, Faculty of Engineering, Kyushu University, Fukuoka 812, Japan Cite this: Chem. Rev. 1997, 97, 5, 1713–1734Publication Date (Web):August 5, 1997Publication History Received31 December 1996Revised19 May 1997Published online5 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/cr960385xhttps://doi.org/10.1021/cr960385xresearch-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views6293Altmetric-Citations1198LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Cavities,Conformation,Hydrocarbons,Nuclear magnetic resonance spectroscopy Get e-Alerts

Sensors for the optical detection ofcyanide ion

2009-09-05

Zhaochao Xu , Xiaoqiang Chen , Ha Na Kim +1 more

This tutorial review focuses on recent developments arising from studies of optical sensors for cyanide ions, which are categorized by approaches involving cyanide selective receptors, the utilization of metal coordinated … This tutorial review focuses on recent developments arising from studies of optical sensors for cyanide ions, which are categorized by approaches involving cyanide selective receptors, the utilization of metal coordinated complexes, and chemodosimeters.

Perspectives in Supramolecular Chemistry—From Molecular Recognition towards Molecular Information Processing and Self‐Organization

1990-11-01

Jean‐Maríe Lehn

Abstract The selective binding of a substrate by a molecular receptor to form a supramolecular species involves molecular recognition which rests on the molecular information stored in the interacting species. … Abstract The selective binding of a substrate by a molecular receptor to form a supramolecular species involves molecular recognition which rests on the molecular information stored in the interacting species. The functions of supermolecules cover recognition, as well as catalysis and transport. In combination with polymolecular organization, they open ways towards molecular and supramolecular devices for information processing and signal generation. The development of such devices requires the design of molecular components performing a given function (e.g., photoactive, electroactive, ionoactive, thermoactive, or chemoactive) and suitable for assembly into an organized array. Light‐conversion devices and charge‐separation centers have been realized with photoactive cryptates formed by receptors containing photosensitive groups. Eleclroactive and ionoactive devices are required for carrying information via electronic and ionic signals. Redox‐active polyolefinic chains, like the “caroviologens”, represent molecular wires for electron transfer through membranes. Push‐pull polyolefins possess marked nonlinear optical properties. Tubular mesophases, formed by organized stacking of suitable macro‐cyclic components, as well as “chundle”‐type structures, based on bundles of chains grafted onto a macrocyclic support, represent approaches to ion channels. Lipophilic macrocyclic units form Langmuir‐Blodgett films that may display molecular recognition at the air‐water interface. Supramolecular chemistry has relied on more or less preorganized molecular receptors for effecting molecular recognition, catalysis, and transport processes. A step beyond preorganization consists in the design of systems undergoing self‐organization, that is, systems capable of spontaneously generating a well‐defined supramolecular architecture by self‐assembling from their components under a given set of conditions. Several approaches to self‐assembling systems have been pursued: the formation of helical metal complexes, the double‐stranded helicates, which result from the spontaneous organization of two linear polybipyridine ligands into a double helix by binding of specific metal ions; the generation of mesophases and liquid crystalline polymers of supramolecular nature from complementary components, amounting to macroscopic expression of molecular recognition; the molecular‐recognition‐directed formation of ordered solid‐state structures. Endowing photo‐, electro‐, and ionoactive components with recognition elements opens perspectives towards the design of programmed molecular and supramolecular systems capable of self‐assembly into organized and functional supramolecular devices. Such systems may be able to perform highly selective operations of recognition, reaction, transfer, and structure generation for signal and information processing at the molecular and supramolecular levels.

Fluorescent Dyes and Their Supramolecular Host/Guest Complexes with Macrocycles in Aqueous Solution

2011-10-07

Roy N. Dsouza , Uwe Pischel , Werner M. Nau

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFluorescent Dyes and Their Supramolecular Host/Guest Complexes with Macrocycles in Aqueous SolutionRoy N. Dsouza†, Uwe Pischel*‡, and Werner M. Nau*†View Author Information† School of Engineering and Science, … ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFluorescent Dyes and Their Supramolecular Host/Guest Complexes with Macrocycles in Aqueous SolutionRoy N. Dsouza†, Uwe Pischel*‡, and Werner M. Nau*†View Author Information† School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany‡ Centro de Investigación en Química Sostenible (CIQSO) and Departamento de Ingeniería Química, Química Física y Química Orgánica, Universidad de Huelva, Campus de El Carmen s/n, E-21071 Huelva, SpainW.M.N.: e-mail, [email protected]; telephone, +49 421 200 3233; fax, +49 421 200 3229. U.P.: e-mail, [email protected]; telephone, +34 959 21 9982; fax, +34 959 21 9983.Cite this: Chem. Rev. 2011, 111, 12, 7941–7980Publication Date (Web):October 7, 2011Publication History Received10 June 2011Published online7 October 2011Published inissue 14 December 2011https://pubs.acs.org/doi/10.1021/cr200213shttps://doi.org/10.1021/cr200213sreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views23664Altmetric-Citations972LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Dyes and pigments,Fluorescence,pH,Phosphates,Reaction products Get e-Alerts

Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species

2016-01-01

Xiaoqiang Chen , Fang Wang , Ji Young Hyun +5 more

Reactive oxygen (ROS) and nitrogen (RNS) species cause oxidative and nitrosative stresses, respectively. These stresses are implicated not only in diverse physiological processes but also in various pathological processes, including … Reactive oxygen (ROS) and nitrogen (RNS) species cause oxidative and nitrosative stresses, respectively. These stresses are implicated not only in diverse physiological processes but also in various pathological processes, including cancer and neurodegenerative disorders. In addition, some ROS and RNS in the environment are pollutants that threaten human health. As a consequence of these effects, sensitive methods, which can be employed to selectively monitor ROS and RNS in live cells, tissues and organisms as well as in environmental samples, are needed so that their biological roles can be understood and their concentrations in environmental samples can be determined. In this review, fluorescent, luminescent and colorimetric ROS and RNS probes, which have been developed since 2011, are comprehensively discussed.

Anion Receptor Chemistry

2006-04-07

Jonathan L. Sessler , Philip A. Gale , Won‐Seob Cho

Anion recognition plays a critical role in a range of biological processes, and a variety of receptors and carriers can be found throughout the natural world. Chemists working in the … Anion recognition plays a critical role in a range of biological processes, and a variety of receptors and carriers can be found throughout the natural world. Chemists working in the area of supramolecular chemistry have created a range of anion receptors, drawing inspiration from nature as well as their own inventive processes. This book traces the origins of anion recognition chemistry as a unique sub-field in supramolecular chemistry while illustrating the basic approaches currently being used to effect receptor design. The combination of biological overview and summary of current synthetic approaches provides a coverage that is both comprehensive and comprehensible. First, the authors detail the key design motifs that have been used to generate synthetic receptors and which are likely to provide the basis for further developments. They also highlight briefly some of the features that are present in naturally occurring anion recognition and transport systems and summarise the applications of anion recognition chemistry. Providing as it does a detailed review for practitioners in the field and a concise introduction to the topic for newcomers, Anion Receptor Chemistry reflects the current state of the art. Fully referenced and illustrated in colour, it is a welcome addition to the literature.

Fluorescent chemosensors: the past, present and future

2017-01-01

Di Wu , Adam C. Sedgwick , Thorfinnur Gunnlaugsson +3 more

Fluorescent chemosensors for ions and neutral analytes have been widely applied in many diverse fields such as biology, physiology, pharmacology, and environmental sciences. Fluorescent chemosensors for ions and neutral analytes have been widely applied in many diverse fields such as biology, physiology, pharmacology, and environmental sciences.

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Calixarene‐Derived Fluorescent Probes

2007-11-15

Jong Seung Kim , Dương Tuấn Quang

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML … Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Coumarin-Based Small-Molecule Fluorescent Chemosensors

2019-07-17

Duxia Cao , Zhiqiang Liu , Peter Verwilst +4 more

Coumarins are a very large family of compounds containing the unique 2H-chromen-2-one motif, as it is known according to IUPAC nomenclature. Coumarin derivatives are widely found in nature, especially in … Coumarins are a very large family of compounds containing the unique 2H-chromen-2-one motif, as it is known according to IUPAC nomenclature. Coumarin derivatives are widely found in nature, especially in plants and are constituents of several essential oils. Up to now, thousands of coumarin derivatives have been isolated from nature or produced by chemists. More recently, the coumarin platform has been widely adopted in the design of small-molecule fluorescent chemosensors because of its excellent biocompatibility, strong and stable fluorescence emission, and good structural flexibility. This scaffold has found wide applications in the development of fluorescent chemosensors in the fields of molecular recognition, molecular imaging, bioorganic chemistry, analytical chemistry, materials chemistry, as well as in the biology and medical science communities. This review focuses on the important progress of coumarin-based small-molecule fluorescent chemosensors during the period of 2012-2018. This comprehensive and critical review may facilitate the development of more powerful fluorescent chemosensors for broad and exciting applications in the future.

Applications of Supramolecular Anion Recognition

2015-05-21

Nathalie Busschaert , Claudia Caltagirone , Wim Van Rossom +1 more

ADVERTISEMENT RETURN TO ISSUEPREVReviewApplications of Supramolecular Anion RecognitionNathalie Busschaert†, Claudia Caltagirone‡, Wim Van Rossom†, and Philip A. Gale*†View Author Information† Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom‡ Dipartimento … ADVERTISEMENT RETURN TO ISSUEPREVReviewApplications of Supramolecular Anion RecognitionNathalie Busschaert†, Claudia Caltagirone‡, Wim Van Rossom†, and Philip A. Gale*†View Author Information† Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom‡ Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, S.S. 554 Bivio per Sestu, 09042 Monserrato, Cagliari, Italy*Phone: +44 23 8059 3332. Fax: +44 23 8059 6805. E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 15, 8038–8155Publication Date (Web):May 21, 2015Publication History Received18 February 2015Published online21 May 2015Published inissue 12 August 2015https://doi.org/10.1021/acs.chemrev.5b00099Copyright © 2015 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoicewith CC-BYlicenseArticle Views48900Altmetric-Citations937LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (64 MB) Get e-AlertscloseSUBJECTS:Anions,Charge transport,Fluorescence,Receptors,Sensors Get e-Alerts

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Transport and Diffusion Across Cell Membranes

1986-01-01

Wilfred D. Stein , W.R. Lieb

Supramolecular chemistry of anions

1997-01-01

Antonio Bianchi , Kristin Bowman‐James , Enrique García‐España

Physical Factors in Anion Separations (B. Moyer & P. Bonnesen). Historical View on the Development of Anion Coordination Chemistry (B. Dietrich & M. Hosseini). Natural Anion Receptors: Anion Recognition by … Physical Factors in Anion Separations (B. Moyer & P. Bonnesen). Historical View on the Development of Anion Coordination Chemistry (B. Dietrich & M. Hosseini). Natural Anion Receptors: Anion Recognition by Proteins (S. Mangani & M. Ferraroni). Artificial Anion Hosts: Concepts for Structure and Guest Binding (F. Schmidtchen). Structural and Topological Aspects of Anion Coordination (J. Atwood & J. Steed). Thermodynamics of Anion Complexation (A. Bianchi & E. Garcia-Espana). Electrochemical Aspects of Anion Chemistry (A. Carbo). Photochemistry and Photophysics of Supramolecular Systems Containing Anions (L. Moggi & M. Manfrin). Anion Binding Receptors: Theoretical Studies (J. Wiorkiewicz-Kuczera & K. Bowman-James). Application Aspects Involving the Supramolecular Chemistry of Anions (J. Sessler, et al.). Supramolecular Catalysis of Phosphoryl Anion Transfer Processes (M. Hasseini). Index.

Imidazole Derivatives as ON/OFF Fluorescent Chemosensor to Detect Mercury Ion: A Mini Review

2025-06-26

Suhail Ahmad , Said R. Rabbani , Umme Salma +1 more | Journal of Fluorescence

π-Conjugated Supramolecular Self-Assembled Fluorescent Sensor Array for Biogenic Amines: A Machine Learning Approach

2025-06-24

Umang Kumar , Gagandeep Singh , Navneet Kaur +1 more | Organic Letters

π-Conjugated supramolecular self-assembled fluorescence sensor arrays have been developed for the detection and discrimination of biogenic amines in food samples utilizing machine learning-assisted statistical algorithms such as principal component analysis … π-Conjugated supramolecular self-assembled fluorescence sensor arrays have been developed for the detection and discrimination of biogenic amines in food samples utilizing machine learning-assisted statistical algorithms such as principal component analysis (PCA), linear discriminant analysis (LDA), and hierarchical cluster analysis (HCA). The developed sensor array system is applied to the real-time and on-site detection of biogenic amines in food samples. Binary and ternary mixture analyses were successfully achieved.

A novel portable colorimetric probe for fast and selective detection of hypochlorite and its applications

2025-06-24

Eunha Han , Yun‐Seo Lee , Soyeon Kim +1 more | Coloration Technology

Abstract A novel portable colorimetric probe TNB ( N ‐(5‐( tert ‐butyl)‐1 H ‐pyrazol‐3‐yl)‐7‐nitrobenzo[c][1,2,5]oxadiazol‐4‐amine) was developed to detect hypochlorite (ClO − ) quickly and simply. Noticeable colour changing from orange … Abstract A novel portable colorimetric probe TNB ( N ‐(5‐( tert ‐butyl)‐1 H ‐pyrazol‐3‐yl)‐7‐nitrobenzo[c][1,2,5]oxadiazol‐4‐amine) was developed to detect hypochlorite (ClO − ) quickly and simply. Noticeable colour changing from orange to colourless was evident in 1 s, upon the addition of ClO − into TNB. The detection limit of TNB for ClO − was 7.00 μM. TNB could reliably quantify ClO − in real water samples and a commercial bleach. The portable colorimetric probe TNB could obviously discern ClO − in varied media using paper kits. Practically, chemosensor TNB was able to quantify the amounts of ClO − with a smartphone application in environmental samples. The detection mechanism of ClO − was proposed to be hydrolytic cleavage reaction through electrospray ionisation‐mass spectrometry (ESI‐MS), proton nuclear magnetic resonance ( 1 H‐NMR) analysis, and density functional theory (DFT) calculations.

Half-Lantern Binuclear Pt(II) Complexes with Heteroleptic Cyclometalated 2-Phenylpyridine Ligands: Synthesis, Metal-Induced Planar Chirality, Chirality Self-Sorting, and Chiroptical Properties

2025-06-24

Bao Zhang , Qingping Yang , Bo Tu +4 more | Organic Letters

Half-lantern binuclear Pt(II) complexes bearing two heteroleptic cyclometalated 2-phenylpyridine ligands were synthesized and characterized for the first time. Heteroleptic cyclometalation is favorable for achieving an asymmetric charge distribution and for … Half-lantern binuclear Pt(II) complexes bearing two heteroleptic cyclometalated 2-phenylpyridine ligands were synthesized and characterized for the first time. Heteroleptic cyclometalation is favorable for achieving an asymmetric charge distribution and for tuning optical properties. The maximum emission wavelength of the heteroleptic cyclometalated complexes is approximately half the sum of those of the corresponding homoleptic cyclometalated complexes. Moreover, their metal-induced planar chirality can be self-sorted by chiral soft-bridged thiolate ligands with a diastereoselectivity exceeding 99%.

Copper ion detection in aqueous media using a carboxamide-based colorimetric sensor and test kit: Synthesis, crystal structures, antimicrobial activity, and computational studies

2025-06-24

Samira Fadaei Heydari , Robabeh Alizadeh , Vahid Amani +1 more | Journal of Water Process Engineering

Efficient Colorimetric Naked-Eye Detection of Lanthanum (La3+) and Ferrous (Fe2+) Ions Using Pyrazole-Based Schiff Base

2025-06-24

Hafiz Muhammad Junaid , Madeeha Batool | Topics in Catalysis

Macrocyclic fluorescent probes for the detection of environmental pollutants: a comprehensive review

2025-06-23

Xuguang Hong , Geng Liu , Chao Yang +7 more | Coordination Chemistry Reviews

Elucidation of Organohalogenochromism (OHC) of D–A Pyridinium and D‐π‐A Pyridinium Dyes: Effect of Halogen Bond

2025-06-23

Kumpei Kozuka , Keiichi Imato , Yousuke Ooyama | Chemistry - An Asian Journal

Bathochromic shift-type OHC (b-OHC) was found in donor-acceptor (D-A) type pyridinium dye bearing halide ion as a counter anion, as well as donor-π-acceptor (D-π-A) type pyridinium dye; the intramolecular charge … Bathochromic shift-type OHC (b-OHC) was found in donor-acceptor (D-A) type pyridinium dye bearing halide ion as a counter anion, as well as donor-π-acceptor (D-π-A) type pyridinium dye; the intramolecular charge transfer-based photoabsorption maxima (λmax abs) in halogenated solvents show a large bathochromic shift, in comparison with those in non-halogenated solvents. It was revealed that there is a good relationship between the most positive surface electrostatic potential (VS,max) values associated with the most positive σ-hole on halogen atoms in organohalogen molecule and the λmax abs, indicating that the b-OHC of the D-A and D-π-A pyridinium dyes is attributed to the formation of halogen bond (XB) or complex such as [R─X·Y]- between the halogen atom (X) of organohalogen molecule and the counter anion (Y) of dye molecule. Moreover, the plots of the λmax abs against the VS,max values demonstrated that the b-OHC characteristic of D-A pyridinium dye is lower than that of the D-π-A pyridinium dye. It was suggested that the formation of XB induces a decrease in the ring current of the pyridinium ring, that the LUMO is mainly localized, resulting in the expression of b-OHC. Consequently, this work offers a deeper insight into the mechanism for the expression and the origin of OHC.

Post-modifiable trapezoidal cage and selective recognition of SO42− from HPO42−-containing environments

2025-06-22

Y.R. Feng , Xiao Ma , Feiying Ruan +2 more | Molecular Diversity

Proton and Metal Dication Affinities of Tetracyclic Imidazo[4,5-b]Pyridine-Based Molecules: Insights from Mass Spectrometry and DFT Analysis

2025-06-21

Lucija Vrban , Ingrid Ana Martinac , Marijana Hranjec +4 more | Molecules

The imidazo[4,5-b]pyridine scaffold, a versatile heterocyclic system, is renowned for its biological and chemical significance, yet its coordination chemistry with biologically relevant metal dications remains underexplored. This study investigates the … The imidazo[4,5-b]pyridine scaffold, a versatile heterocyclic system, is renowned for its biological and chemical significance, yet its coordination chemistry with biologically relevant metal dications remains underexplored. This study investigates the proton and metal dication affinities of twelve tetracyclic organic molecules based on the imidazo[4,5-b]pyridine core, focusing on their interactions with Ca(II), Mg(II), Zn(II), and Cu(II). Employing a dual approach of electrospray ionization mass spectrometry (ESI-MS) and density functional theory (DFT) calculations, we characterized the formation, stability, and structural features of metal–ligand complexes. ESI-MS revealed distinct binding behaviors, with Cu(II) and Zn(II) forming stable mono- and dinuclear complexes, often accompanied by reduction processes (e.g., Cu(II) to Cu(I)), while Ca(II) and Mg(II) exhibited lower affinities. DFT analysis elucidated the electronic structures and thermodynamic stabilities, highlighting the imidazole nitrogen as the primary binding site and the influence of regioisomeric variations on affinity. Substituent effects were found to modulate binding strength, with electron-donating groups enhancing basicity and metal coordination. These findings provide a comprehensive understanding of the coordination chemistry of imidazo[4,5-b]pyridine derivatives, offering insights into their potential applications in metalloenzyme modulation, metal-ion sensing, and therapeutic chelation.

Multifunctional Schiff Base Chemosensor for Cu2+ and 2,4-D Sensing with Potent Antibacterial Activity

2025-06-21

Faris J. Tayeb , Alaa Shafie , Mohammed Fareed Felemban +1 more | Journal of Fluorescence

Detection of two-dimensional symmetry protected topological order with partial symmetries

2025-06-20

NULL AUTHOR_ID | Physical review. B./Physical review. B

An Aggregation/Monomer-Based Probe for Monitoring Mitochondria–Lysosome Interactions during Cuproptosis

2025-06-20

Cui Zhou , Jia-Tong Yan , Yi-Ting Chu +6 more | Analytical Chemistry

The interplay between lysosomes and mitochondria is essential for maintaining cellular function, and disruptions of their interaction have been implicated in the onset of various diseases. Small molecule fluorescent probes … The interplay between lysosomes and mitochondria is essential for maintaining cellular function, and disruptions of their interaction have been implicated in the onset of various diseases. Small molecule fluorescent probes are powerful tools for monitoring these biological processes. However, a comprehensive strategy for designing small-molecule probes capable of dual-color visualization of both mitochondria and lysosomes remains lacking. In this study, we introduce MISO, a noninvasive small organic molecular probe, as an effective tool for tracking the dynamic interplay between mitochondria and lysosomes in living cells. Mechanistic studies revealed that MISO targets lysosomes in a monomeric state, exhibiting green fluorescence, and in an aggregated state within mitochondria, displaying red fluorescence. Using MISO, we were able to perform long-term tracking of dynamic mitochondria-lysosome interactions and identified several distinct types of interactions between these organelles. Notably, for the first time, MISO revealed changes in mitochondria-lysosome interactions during cuproptosis, suggesting that the modulation of these interactions may influence this form of cell death. This work presents a valuable tool for real-time monitoring of functional mitochondria-lysosome interactions in living cells and opens avenues for advancing our understanding of related cellular processes and disease mechanisms.

Chromotropic acid-activated silver nanoparticles: a convenient colorimetric sensor for selective determination of divalent and trivalent iron ions

2025-06-20

Nam-Phuong Nguyen-Huynh , Hong-Phuong Phan , Hoa-Hung Lam +5 more | Chemical Papers

Rhenium(I) tricarbonyl complexes appended to oxathiacrown ethers as selective optical sensing probes for mercury(II) ions

2025-06-20

Ruth A. Odhiambo , Lydia W. Njenga | Environmental Monitoring and Assessment

An ICT-FRET fluorescent probe for ratiometric recognition of hydrogen peroxide utilizing coumarin-naphthalimide derivative

2025-06-19

Qiujuan Ma , Junhong Xu , Shuangyu Liu +3 more | Dyes and Pigments

Redox behavior of ferrocene-methanol encapsulated in hydrophobic nanotubes

2025-06-19

Fadwa Alfadel Raad , Pierre Picot , Elodie Barruet +4 more | Applied Clay Science

A NIR dual-channel fluorescent probe for the detection of cyanide in living cells

2025-06-18

Yongqiang Xie , Quan‐Ling Suo , Shan Jiang +7 more | Photochemical & Photobiological Sciences

Encapsulating Ionophores in Zeolite Imidazolate Framework‐8 for Long‐term Monitoring of Ion Fluctuations in Living Rat Brain

2025-06-18

Rantong Liu , Shuai Zhang , Guoyuan Ren +6 more | Angewandte Chemie International Edition

Various ions in the brain (e.g., H+, K+ and Ca2+) play essential roles in neural information transmission and physio‐pathological processes. Real‐time monitoring of these ions will provide critical information for … Various ions in the brain (e.g., H+, K+ and Ca2+) play essential roles in neural information transmission and physio‐pathological processes. Real‐time monitoring of these ions will provide critical information for understanding neural functions and diagnosing diseases. However, long‐term monitoring the dynamics of ions with microelectrodes remains a challenge due to the limited availability of sensing strategies capable of in vivo measurements with high stability in the mechanically soft and chemically complex brain of freely moving rats. Here, we develop a flexible and stable ion‐selective microsensor for long‐term monitoring of ions in rat brain, in which zeolite imidazolate framework‐8 (ZIF‐8) nanoparticles incorporated with ionophores are used for selective ion recognition and flexible polyvinyl alcohol (PVA) fibers sputtered gold nanoparticles (AuNP) is used as the soft electrode substrate. The flexible microsensors allow long‐term in vivo ion sensing with good stability in the brain of behaving rat, avoiding progressively deteriorating response of traditional polymer‐based rigid ion selective microsensor caused by its instability interface and mechanical mismatch to soft brain tissue.

A Coumarin-Julolidine conjugated novel Schiff base: synthesis, DFT insights, and evaluation of selective and sensitive dual-responsive fluorescence sensing capabilities with Cu+ and Cu2+ ions

2025-06-18

Raghvendra Niranjan , G. Durga Prasad , Mariyaraj Arockiaraj +3 more | Chemical Physics

Enantioselective Electrochemical Detection of Tyrosine Isomers Using Chiral Crown Ether–Modified MWCNTs Electrodes

2025-06-18

Sharad S. Upadhyay , Mushtaq Ahmad Dar , Nayan S. Gadhari +4 more | Journal of The Electrochemical Society

Abstract An electrochemical method for enantiorecognition of tyrosine isomers (D-TYR and L-TYR) using a carbon paste electrode modified with SSSS-TCA-embedded MWCNTs has been developed. The nanocavity of SSSS-TCA serves as … Abstract An electrochemical method for enantiorecognition of tyrosine isomers (D-TYR and L-TYR) using a carbon paste electrode modified with SSSS-TCA-embedded MWCNTs has been developed. The nanocavity of SSSS-TCA serves as a host-guest interaction site where the amino group of TYR forms tripodal intermolecular hydrogen bonds that account for the difference in electrode potential. Complexation is taken as a measure of enantioselectivity, with SSSS-TCA forming a 1:1 inclusion complex with D-TYR and L-TYR, exhibiting stability constant values of 552 M⁻¹ and 343 M⁻¹, respectively. Sensor shows the discernible difference in the oxidation peak potential for TYR isomers (ΔEp(L-TYR–D-TYR) = 102 mV) employing differential pulse voltammetry. Consequently, the sensor can distinguish TYR enantiomers by achieving an enantiomeric electrochemical difference ratio (IL/ID) of 4.3. A linear relationship was observed between the TYR peak current and its concentration over the range of 2.1 to 140 µM. The limits of detection were 0.51 µM for L-TYR and 0.264 µM for D-TYR, indicating high sensitivity of the sensor. Moreover, the sensor demonstrated excellent selectivity, showing minimal interference from structurally similar compounds and other potential interfering species. The sensor was applied to estimate the amount of TYR isomers in the racemic mixture and biological fluids.

Red Emitting Fluorescent EuDPA Complex as a Probe for the Detection of Serotonin, A Neurotransmitter

2025-06-18

N. S. Vijila , Merin K. Abraham , Greeshma Rajeevan +3 more | Journal of Fluorescence

Chloride Selective, Non‐protonophoric Ion Transport with Macrocyclic Halogen Bonding Anionophores

2025-06-18

Martin Flerin , Fernanda Duarte , Matthew J. Langton | Chemistry - A European Journal

Synthetic ion transporters hold promise as both chemical probes and potential therapeutics for diseases linked to malfunctioning protein ion transporters. However, their application in biological systems is limited, partly due … Synthetic ion transporters hold promise as both chemical probes and potential therapeutics for diseases linked to malfunctioning protein ion transporters. However, their application in biological systems is limited, partly due to the cytotoxicity arising from unselective ion transport. Here, we demonstrate that highly active and selective anionophores can be accessed by combining halogen bonding anion recognition with macrocyclic anion encapsulation. Anion transport experiments in large unilamellar vesicles revealed over 300‐fold selectivity for chloride transport over proton/hydroxide ions, which is key for potential future therapeutic applications, where the dissipation of cellular pH gradients must be avoided. The mechanism underpinning selectivity is studied through Density Functional Theory (DFT) calculations and MD simulations at the membrane interface, demonstrating that the cyclic structure imposes an energetic preference for chloride binding over hydroxide, as well as a greater desolvation of hydroxide, which further disfavours its transport. We anticipate that these results will accelerate the transition towards the use of artificial chloride transport in biology.

Aqueous-Phase Degradation Mechanism of Parabens, Emerging Contaminants, by Peroxynitrite

2025-06-18

Clara I. Alcolado , Elena Jiménez , Luis García‐Río +1 more | ACS ES&T Water

A dual-site fluorescent probe for colorimetric detection of FA and its application in poultry products chicken feet

2025-06-18

Xiaoming Wu , Leyuan Ding , Shaoxiang Yang +2 more | Journal of Food Composition and Analysis

A Gadolinium Metal‐Based Fluorescent Probe for Selective Detection of Phenazopyridine Hydrochloride

2025-06-18

Lanqing Liu , Xiaomei Wang , L. Gong +2 more | Applied Organometallic Chemistry

ABSTRACT Rapid and accurate detection of phenazopyridine hydrochloride (PAP) is essential for protecting public health and safety. In this paper, gadolinium‐based coordination polymer [Gd(adip) 1/2 (NMP) 2 (CH 3 COO)]·H … ABSTRACT Rapid and accurate detection of phenazopyridine hydrochloride (PAP) is essential for protecting public health and safety. In this paper, gadolinium‐based coordination polymer [Gd(adip) 1/2 (NMP) 2 (CH 3 COO)]·H 2 O ( 1 ) has been synthesized using a solvothermal method centered on gadolinium metal with the ligand 5,5′‐(anthracene‐9,10‐diyl)‐diisophthalic acid (H 4 adip). It was characterized with various instruments and served as a fluorescence‐based sensing platform to measure PAP. Under 375 nm excitation, 1 displays an emission maximum at 427 nm and a shoulder peak at 409 nm. When used as a sensor, Compound 1 can quantitatively detect PAP in the 0–41.2 μM concentration range, with a LOD of 0.024 μM. Mechanistic studies have shown that the addition of PAP significantly quenches the fluorescence emission of 1 through the fluorescence resonance energy transfer (FRET) mechanism. In summary, 1 not only provides highly sensitive and selective detection of PAP, but is also reusable.

Terpyridine-Based Sensors for Metal Ion Detection: High Sensitivity, Selectivity, and Computational Analysis of Binding Mechanisms

2025-06-17

Ehsan Ullah Mughal , Nafeesa Naeem , Ebru Bozkurt +5 more | Journal of Inorganic and Organometallic Polymers and Materials

Merocyanine-Based Near-infrared Molecular Rotor for Monitoring Viscosity Changes in Living Cells

2025-06-17

Lingyan Wang , Xu Ding , Hao Bai +4 more | Talanta

Development of N,O-benzamide Borondifluoride-based Lipid Droplets-Targeting Fluorescent Probes for Fatty Liver Identification

2025-06-17

Yang Liu , Yixin Zhang , S. He +6 more | Dyes and Pigments

A novel ESIPT fluorescent probe based on 1,3,4-thiadiazole and coumarin for sequential detection of Cu2+ and H2S and its application in food samples

2025-06-17

Meng Zhao , Ruyi Ma , Zihan Wang +2 more | Food Chemistry

Terpyridine-Based Fluorescent Sensors: Investigating the Analytical Properties for Diverse Applications

2025-06-16

Neelam Gupta , Dheeraj Pandey , Jyoti Pandey +2 more | Critical Reviews in Analytical Chemistry

The research area involving fluorescent probes have gained attention in recent years due to their multiple advantages including ease of visualization, simplicity of use, instant biological imaging, and cost-effectiveness. Several … The research area involving fluorescent probes have gained attention in recent years due to their multiple advantages including ease of visualization, simplicity of use, instant biological imaging, and cost-effectiveness. Several fluorescent cores are available that can be used to design fluorescent sensors for various applications. Terpyridine is a core that has been widely synthesized involving carbon-carbon coupling reactions or by central ring assembly. The lateral phenyl (4'-phenyl) position of terpyridine can be functionalized easily by incorporation of additional organic functionalities that makes terpyridine more advantageous and highly explored fluorescent core. The emission wavelength of terpyridine can be tuned on substitution of electron withdrawing or donating functionalities. Terpyridine based probes has been reported for their use in environmental application, such as sensing of cation and anion, nerve agent in water, food, milk, cell imaging and disease diagnosis, etc. In this review we have compiled the recent developments in terpyridine based sensors that can be utilized for biological and non-biological applications. The mechanism of sensing along with the limit of detection and photophysical parameters of terpyridine based sensors have been discussed. The applications ranging from cell imaging, sensing of pH, detection of citrate, oxygen, H2S, nitro aromatic compounds, sulfonamide antibiotics, vitamin C, single oxygen, and radioactive metals, such as uranium in variety of sample matrix is covered in this review. In this review we have incorporated the most common synthetic methods for synthesis of terpyridine core using the cross-coupling reaction and central ring assembly.

A novel N-alkyhydrazone-based Iridium(III) complex for luminescence imaging of mitochondrial hypochlorous acid in liver injury

2025-06-16

Lingtan Kong , Ling Wang , Shaozhen Jing +3 more | Analytica Chimica Acta

Dual fluorophores embedded into zeolitic imidazolate framework-8 for ratiometric fluorescence monitoring of pH and histamine in seafood samples and bioimaging

2025-06-16

Xiaoran Zhang , Muhammad Asif , Ayesha Aziz +6 more | Talanta

Chiral Aromatic Micelles as Chiroptical Host Tools for Large Metallodyes in Water

2025-06-15

Yoshihisa Hashimoto , Yuya Tanaka , Siyu Liu +2 more | Journal of the American Chemical Society

In contrast to abundant aliphatic chiral cavities in nature, synthetic chiral cavities formed by self-assembly of aromatic subunits are quite rare, particularly providing an ability in induced chirality. Here, we … In contrast to abundant aliphatic chiral cavities in nature, synthetic chiral cavities formed by self-assembly of aromatic subunits are quite rare, particularly providing an ability in induced chirality. Here, we report new chiral aromatic micelles capable of inducing the optical chirality of large metallodyes upon encapsulation. The aromatic micelle, with a core diameter of ∼3 nm, forms from axially chiral amphiphiles featuring a bent mesityl-substituted BINOL framework. Unlike alkyl and aromatic micelles reported previously, the obtained micelle emits strong fluorescence (ΦF > 40%) through the aggregation-induced emission effect in water. The adaptable chiral cavity of the micelle efficiently encapsulates several kinds of achiral metallodyes, such as metalated porphyrins and norcorroles, to afford aqueous host-guest composites, displaying efficient dye-based induced chirality through multiple CH-π interactions. Remarkably, the chirality induction of metallophthalocyanine, bearing a completely planar framework, and its stacked dimer can also be demonstrated (up to |gabs| = 2.4 × 10-3) in the cavity under ambient aqueous conditions. To the best of our knowledge, the present aromatic micelles are the first host tools to induce the chiral properties of common to rare metallodyes, without additional covalent functionalizations. The chiroptical properties of the obtained host-guest composites are further tunable (i.e., 0.1- to 1.6-fold intensity) upon thermal stimuli in an irreversible fashion without disassembly.

Construction of FRET-based CDs@RBH Ratiometric Fluorescent Probe for Cu2+ Sensing

2025-06-14

Xuemei Dong , Zhongfei Hu , Xuan Xiao +2 more | Journal of Fluorescence

A Review of the Molecular Aggregation of Small-Molecule Anion Sensors for Environmental Contaminates in Aqueous Media

2025-06-14

Mallory E. Thomas , Alistair J. Lees | Sustainable Chemistry

A primary challenge in the further development of anion sensors in real water samples of environmental concern is the need for highly water-soluble compounds that are able to detect low … A primary challenge in the further development of anion sensors in real water samples of environmental concern is the need for highly water-soluble compounds that are able to detect low concentrations of analytes. Small-molecule sensors can mitigate solubility constraints and highly aromatic or conjugated systems may provide a new way to recognize target analytes with high sensitivity and/or selectivity. Organic aggregates that have the ability to form large frameworks can exhibit aggregated-induced emissions to detect target analytes, and their coagulation can provide enhanced detection via colorimetric or fluorescent measurements. This review aims to draw attention to the emerging area of small-molecule organic chemosensors that utilize aggregation to detect environmentally detrimental anions in an aqueous solution. A number of mechanisms of interaction for anion recognition are recognized and discussed here, including electrostatic interactions, covalent bond formation, hydrophobic interactions, and even complexation.

In-situ Visualization of Level 3 LFPs Using a Lipophilic Red AIE Fluorescent Probe with a D–A Structure

2025-06-14

Qi Guo , Liqin Lu , Jiansen Wen +1 more | Journal of Fluorescence

Monitoring pH in lysosomes of living cells using a pH-sensitive probe based on spirocyclization strategy

2025-06-14

Yu Xue , Dan Wang , Mengjuan Shi +3 more | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

Development of a benzothianone-based NIR fluorescent probe and its application of Pd0 detection in bioimaging and smartphone-assisted water samples

2025-06-13

Youlai Zhang , Aojie Dai , Haoyu Wu +6 more | Journal of Photochemistry and Photobiology A Chemistry

The classification of endotrivial complexes

2025-06-12

Sam K. Miller | Advances in Mathematics

Imidazole-based highly selective and sensitive carbonate anions chemosensor: Design, synthesis, characterization, DFT, and biological screening

2025-06-12

Chandana Pramanik , Abhimanyu Jana , Pradip Bera +4 more | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

A multifunctional water-soluble fluorescent probe based on naphthylimide for detection of Hg2+ and formaldehyde with its multi-field applications

2025-06-12

Shukui Pang , Yanchao Yu , Jun You +3 more | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

Sequential Dynamic Fluorescence Switching Driven by Oxa-/Thiol-Michael Conjugate Addition–Elimination Reactions

2025-06-12

Xiangkun Si , Xiaolong Sun | Organic Letters

A dynamic molecular system undergoing sequential reconfiguration and multi-state fluorescence switching via intramolecular oxa/thiol-Michael conjugate addition-elimination reactions is reported. Triggered sequentially by chemical, solvent, and most importantly pH stimuli, the … A dynamic molecular system undergoing sequential reconfiguration and multi-state fluorescence switching via intramolecular oxa/thiol-Michael conjugate addition-elimination reactions is reported. Triggered sequentially by chemical, solvent, and most importantly pH stimuli, the controlled progression through distinct molecular states was monitored by ratiometric absorption/fluorescence and NMR spectroscopy. This stimulus-controlled fluorescence switching demonstrates utility for real-time monitoring of processes, like chemically induced polymer degradation.

A Theoretical Investigation of the Selectivity of Aza-Crown Ether Structures Chelating Alkali Metal Cations for Potential Biosensing Applications

2025-06-12

Mouhmad Elayyan , Mark R. Hoffmann , Binglin Sui | Molecules

Aza-crown ether structures have been proven to be effective in constructing fluorescent biosensors for selectively detecting and imaging alkali metal ions in biological environments. However, choosing the right aza-crown ether … Aza-crown ether structures have been proven to be effective in constructing fluorescent biosensors for selectively detecting and imaging alkali metal ions in biological environments. However, choosing the right aza-crown ether for a specific alkali metal ion remains challenging for synthetic chemists because theoretical guidance on the chelating activities between aza-crown ethers and alkali metal ions has not been available up to now. Predicting the physical properties of the chelator–metal complexations poses a greater challenge due to the numerous quantum mechanical functionals and basis sets to be used in any theoretical investigation. In this study, we report a theoretical investigation of different aza-crown ether structures and their selectivities to alkali metal ions via a novel relationship between the binding energy and charge transfer calculated using twelve different quantum mechanical methods, using a myriad of bases, within the Jacob’s Ladder of Chemical Accuracies. Furthermore, this report represents a guide for the synthetic chemist in the selection of aza-crown ethers in the capturing of specific alkali metal ions, primary objectives, while benchmarking different quantum mechanical calculations, as a secondary objective.